Involvement of Na+/Ca2+ Exchanger in Pentylenetetrazol-Induced Convulsion by Use of Na+/Ca2+ Exchanger Knockout Mice

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概要

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• Involvement of Na+/Ca2+ exchanger (NCX) in pentylenetetrazol (PTZ)-induced convulsion by use of NCX knockout mice and the selective ligand SEA0400 to NCX was examined. In the SEA0400-administered group, the latency to clonic convulsion was extended into 210 s, although the latency to clonic convulsion was observed until 100 s in control group. SEA0400 had little effect on bicuculline-induced clonic seizure nicotine-induced wild running and 4-aminopyridine-induced tonic flexion, respectively. Tonic flexion convulsion was occurred three fifth in the wild type mice group by administration of PTZ, but tonic flexion was not observed in NCX1 knockout mice groups. These results suggest that NCX is involved in inhibitory action in PTZ-induced convulsion.

• 公益社団法人　日本薬学会の論文

著者

• Honda Kenji

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Takano Yukio

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• SAITO Ryo

  Department of Physics, Graduate School of Science, The University of Tokyo

• Komuro Issei

  Department of Cardiovascular Science and Medicine, Chiba University graduate School of Medicine

• Baba Akemichi

  Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit

• Takano Y

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn

• Iwamoto Takahiro

  Department of Pharmacology, Fukuoka University

• MATSUDA Toshio

  Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University

• KITA Satomi

  Department of Pharmacology, Osaka University of Pharmaceutical Sciences

• Takano Yukio

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Kita Satomi

  Department Of Pharmacology Faculty Of Medicine Fukuoka University

• Komuro Issei

  Department Of Cardiovascular Medicine Chiba University School Of Medicine

• TANAKA Yusuke

  Department of Electrical and Electronics Engineering, Graduate School of Engineering, Kobe Universit

• Iwamoto Takahiro

  Department Of Medical Engineering And Cardiology Institute Of Development Aging And Cancer Tohoku Un

• Saito Ryo

  Department Of Environmental Management Studies Information Mathematics Rakuno Gakuen University

• Takano Yukio

  Department Of Applied Physics Faculty Of Engineering University Of Tokyo

• Matsuda Toshio

  Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University

• Baba Akemichi

  Laboratory Of Molecular Neuropharmacology

• Kaneko Erina

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Saito Ryo

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda Kenji

  Department Of Chemistry Toho University

• Saito Ryo

  Department Of Bioscience And Bioinformatics Faculty Of Computer Science And Systems Engineering Kyus

• Tanaka Yusuke

  Department Of Chemistry And Chemical Biology Graduate School Of Engineering Gunma University

• Tanaka Yusuke

  Department Of Applied Chemistry Graduate School Of Engineering Kyushu University

• Komuro Issei

  Department Of Cardiovascular Medicine

• Baba Akemichi

  Laboratory of Veterinary Pharmacology, Graduate School of Life and Environmental Science, Osaka Prefecture University

• Tanaka Yusuke

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

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