Roles of Substance P and NK_1 Receptor in the Brainstem in the Development of Emesis

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概要

• 論文の詳細を見る

• The emetic response is primarily a protective reflex occurring in a wide variety of vertebrates in response to the ingestion of toxic compounds. The role of the nuclei in the brainstem, including the area postrema, nucleus tractus solitarius, the dorsal motor nucleus of the vagus, and the central pattern generator for vomiting, as well as the involvement of the abdominal visceral innervation relevant to the emetic reflex, have all been discussed by many researchers. The introduction of serotonin 5-HT3-receptor antagonists into clinical practice allowed for a dramatic improvement in the management of vomiting. However, vomiting still remains a significant problem. The mechanism of the emetic response is even more complicated than was first thought. This review attempts to bring together some of the evidence suggesting the roles of substance P and its receptor, neurokinin NK1 receptor, in the brainstem nuclei in the development of emesis. Accordingly, NK1-receptor antagonists might represent novel drugs for the management of major types of emesis.

• 社団法人 日本薬理学会の論文
• 2003-02-01

著者

• Takano Yukio

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• SAITO Ryo

  Department of Physics, Graduate School of Science, The University of Tokyo

• Kamiya H

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Science Fukuoka University

• Takano Y

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn

• Takano Y

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Takano Yukio

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• KAMIYA Hiro-o

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Saito Ryo

  Department Of Environmental Management Studies Information Mathematics Rakuno Gakuen University

• Takano Yukio

  Department Of Applied Physics Faculty Of Engineering University Of Tokyo

• Kamiya Hiro-o

  Department Of Pharmacology Faculty Of Phamaceutical Sciences Fukuoka University

• Kamiya Hiro-o

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Saito Ryo

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Kamiya Hiro-o

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Saito Ryo

  Department Of Bioscience And Bioinformatics Faculty Of Computer Science And Systems Engineering Kyus

• Saito Ryo

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science

• KAMIYA Hiro-o

  Department of Pharmaceutical Sciences, Fukuoka University

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