Relationship between Substance P-Induced Initial Transient Contractions and Inositol Phospholipid Hydrolysis in Guinea Pig Ileum

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概要

• 論文の詳細を見る

• The effects of neomycin on substance P (SP)-induced inositol phospholipid hydrolysis and muscle contraction were studied in longitudinal smooth muscle of guinea pig ileum. Various tachykinin peptides including SP stimulated inositol phospholipid hydrolysis in guinea pig ileum. Neomycin (2.5mM) reduced both the contractions and the accumulation of [^3H] inositol phosphates induced by SP. These results suggest that the initial transient contractions induced by SP are coupled to inositol phospholipid hydrolysis.

• 公益社団法人日本薬学会の論文

著者

• Honda Kenji

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Takano Yukio

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Kamiya H

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Science Fukuoka University

• Takano Y

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn

• Takano Y

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda K

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• YAMADA AKIKO

  Department of Pediatrics, Faculty of Medicine, Fukui Medical University

• Honda K

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn

• Kamiya Hiroo

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Takano Yukio

  Department Of Applied Physics Faculty Of Engineering University Of Tokyo

• Kamiya Hiro-o

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda Kenji

  Department Of Chemistry Toho University

• Kamiya Hiro-o

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Yamada Akiko

  Department Of Mathematical And Physical Science Japan Women's University

• Yamada Akiko

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Yamada Akiko

  Department of Internal Medicine,Osaka Ekisaikai Hospital

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