The Spinal Muscarinic M_1 Receptors and GABA_A Receptors Contribute to the McN-A-343-Induced Antinociceptive Effects During Thermal Stimulation of Mice

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概要

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• The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxious thermal stimulation in a dose-dependent manner (31.5 – 63.0 nmol). This McN-A-343–induced antinociceptive effect was dose-dependently inhibited by intrathecal (i.t.) injection of a nonselective muscarinic receptor antagonist atropine, the selective muscarinic M1 antagonist pirenzepine, or the M4 antagonist himbacine. The inhibition of pirenzepine was greater than that of himbacine. In contrast, the selective muscarinic M2 antagonist methoctramine did not inhibit the antinociceptive effects of McN-A-343. In addition, the McN-A-343–induced antinociceptive effect was attenuated by i.t. injection of the GABAA antagonist bicuculline, but not by injection of the GABAB antagonist CGP35348. These results suggest that McN-A-343 produces its antinociceptive effect on the response to thermal stimulation via spinal muscarinic M1 receptors and, at least in part, through neuronal pathways involving spinal GABAA receptors in mice.

• 社団法人 日本薬理学会の論文
• 2008-12-20

著者

• Migita Keisuke

  Department of Neurophysiology, Hirosaki University Graduate School of Medicine

• Honda Kenji

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Takano Yukio

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• KAWATA Satoshi

  Department of Chemistry, Graduate School of Science, Osaka University

• Takano Y

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Takano Yukio

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda Kenji

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Migita Keisuke

  Department Of Neurophysiology Hirosaki University Graduate School Of Medicine

• Kawata Satoshi

  Department Of Applied Physics Graduate School Of Engineering Osaka University

• Kawata Satoshi

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• KOGA Kohei

  Department of Integrative Physiology, School of Medicine, Kyushu University

• Takano Yukio

  Department Of Applied Physics Faculty Of Engineering University Of Tokyo

• Koga Kohei

  Department Of Integrative Physiology School Of Medicine Kyushu University

• Ando Suguru

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda K

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ.

• HORIKAWA Keigo

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Horikawa Keigo

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda Kenji

  Department Of Chemistry Toho University

• Kawata Satoshi

  Department Of Appkied Physicy Osaka University

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