Substance P Causes Adhesion of Neutrophils to Endothelial Cells via Protein Kinase C
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概要
- 論文の詳細を見る
The sensory neuropeptide substance P is known to be involved in neurogenic inflammation. We examined the effect of substance P on neutrophil adhesion to human umbilical vein endothelial cells (HUVEC). Stimulation of HUVEC with substance P increased their adhesion to neutrophils in a time- and concentration (10-<-10>-10^<-7> M)-dependent manner. The adhesion was inhibited by the tachykinin NK_1 receptor antagonist (+)-(2S, 3S)-3-(2-Methoxybenzylamino)-2-phenylpiperidine (CP-99,994) and also by the protein kinase C inhibitors 1-(5-Isoquinolinesulfonyl)-2-methyl piperazine (H-7) and bisindolylmaleimide (BIM), but not by the protein kinase A inhibitor N-[2-(p-Bromocinnamylamino) ethyl]-5-isoquinoline sulfonamide (H-89). These results indicate that substance P induces adhesion of neutrophils to HUVEC by activation of protein kinase C via the NK_1 receptor on the HUVEC.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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Honda Kenji
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Takano Yukio
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Kamiya H
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Science Fukuoka University
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Takano Y
Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn
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Takano Y
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Takano Yukio
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda Kenji
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Honda K
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Tominaga Koji
Department Of Industrial Chemistry Faculty Of Engineering Chubu University
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Tominaga Koji
Department Of Pharmacology Faculty Of Medicine Fukuoka University
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KAMIYA Hiro-o
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Honda K
Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn
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Takano Yukio
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Makino Y
Kanto‐shin'etsu Regional Narcotic Control Office Tokyo Jpn
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Makino Yasuo
Faculty Of Pharmaceutical Sciences And Department Of Gynecology Faculty Of Medicine Fukuoka Universi
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Kamiya Hiro-o
Department Of Pharmacology Faculty Of Phamaceutical Sciences Fukuoka University
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AKAHOSHI Aya
Laboratory of Pharmacokinetics and Pharmacology Panapharm Laboratories Co., Uto,
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KAWARABAYASHI Tatsuhiko
Faculty of Pharmaceutical Sciences and Department of Gynecology, Faculty of Medicine, Fukuoka Univer
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Kamiya Hiro-o
Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Akahoshi Aya
Laboratory Of Pharmacokinetics And Pharmacology Panapharm Laboratories Co. Uto
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Honda Kenji
Department Of Chemistry Toho University
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Kamiya Hiro-o
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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KAWARABAYASHI Tatsuhiko
Faculty of Pharmaceutical Sciences and Department of Gynecology, Faculty of Medicine, Fukuoka University
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KAMIYA Hiro-o
Department of Pharmaceutical Sciences, Fukuoka University
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