Effects of HSP-117, a Novel Tachykinin NK_1-Receptor Antagonist, on Cisplatin-Induced Pica as a New Evaluation of Delayed Emesis in Rats

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概要

• 論文の詳細を見る

• The effects of a novel tachykinin NK1-receptor antagonist HSP-117 {(2S,3S)-3-[(5-isopropyl-2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpiperidine dihydrochloride} on cisplatin-induced pica, i.e., the eating of nonnutritive substances such as kaolin were examined in rats. HSP-117 inhibited kaolin intake in a dose-dependent manner for 2 days. The 5-HT3-receptor antagonist ondansetron inhibited only on the first day, but not on the second day. These results indicate that the cisplatin-induced kaolin intake on the first day is related to both 5-HT3- and NK1 receptors, while only the NK1 receptor is involved on the second day. Thus, cisplatin-induced continuous pica in rats represents a useful model of not only acute but also delayed emesis.

• 社団法人 日本薬理学会の論文
• 2001-07-01

著者

• Takano Yukio

  Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• SAITO Ryo

  Department of Physics, Graduate School of Science, The University of Tokyo

• Ariumi Hideto

  Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute

• Kamiya H

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Science Fukuoka University

• Takano Y

  Dep. Of Physiology And Pharmacology Fac. Of Pharmaceutical Sciences Fukuoka Univ. Jpn

• Takano Y

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Ariumi Hideto

  Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute

• Ariumi Hideto

  久光製薬

• Ariumi Hideto

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• YAMATODANI Atsushi

  Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka Universi

• Takano Yukio

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• SAEKI Masakazu

  Fundamental Research Laboratories, Hisamitsu Pharmaceutical Co., Inc.

• SAKAI Michinori

  Fundamental Research Laboratories, Hisamitsu Pharmaceutical Co., Inc.

• KUBOTA Hisahiko

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• KAMIYA Hiro-o

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Saito Ryo

  Department Of Environmental Management Studies Information Mathematics Rakuno Gakuen University

• Yamatodani Atsushi

  Department Of Bioinformatics Graduate School Of Allied Health Sciences Faculty Of Medicine Osaka Uni

• Yamatodani Atsushi

  Department Of Medical Physics School Of Allied Health Sciences Faculty Of Medicine Osaka University

• Yamatodani Atsushi

  School Of Allied Health Sciences Osaka University Faculty Of Medicine

• Takano Yukio

  Department Of Applied Physics Faculty Of Engineering University Of Tokyo

• Kamiya Hiro-o

  Department Of Pharmacology Faculty Of Phamaceutical Sciences Fukuoka University

• Sakai Michinori

  Fundamental Research Laboratories Hisamitsu Pharmaceutical Co. Inc.

• Saeki Masakazu

  Fundamental Research Laboratories Hisamitsu Pharmaceutical Co. Inc.

• Kamiya Hiro-o

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Kubota Hisahiko

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Saito Ryo

  Department Of Physiology And Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Kamiya Hiro-o

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Fukuoka University

• Sakai Michinori

  Fundamental Research Laboratories Development Assessment Center R&d Division Hisamitsu Pharmaceu

• Saito Ryo

  Department Of Bioscience And Bioinformatics Faculty Of Computer Science And Systems Engineering Kyus

• Saito Ryo

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science

• KAMIYA Hiro-o

  Department of Pharmaceutical Sciences, Fukuoka University

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