Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine (SB-tPS) Reduces Ischemic Damage in the Gerbil Hippocampus
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概要
- 論文の詳細を見る
Mongolian gerbils orally administered with soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS, 240 mg/kg) for 5 days were subjected to cerebral ischemia by bilateral common carotid artery occlusion. The pyramidal cell damage of the hippocampal CA1 subfield was classified into 4 grades according to the proportion of damaged neurons on the tenth day after the ischemic treatment. The damage score of the SB-tPS group was statistically less than that of the control group. This suggests that the pre-administration of SB-tPS may relieve the delayed neuronal cell death caused by cerebral ischemia.
- 社団法人 日本薬理学会の論文
著者
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Kudo Satoshi
Yakult Central Institute For Microbiological Research
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Suzuki Shinji
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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Takahashi Masatoshi
Yakult Central Institute For Microbiological Research
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Suzuki S
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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SUZUKI Satoru
Yakult Central Institute for Microbiological Research
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FURUSHIRO Masayoshi
Yakult Central Institute for Microbiological Research
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SAKAI Masashi
Yakult Central Institute for Microbiological Research
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Sakai Michinori
Fundamental Research Laboratories Hisamitsu Pharmaceutical Co. Inc.
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Saeki Masakazu
Fundamental Research Laboratories Hisamitsu Pharmaceutical Co. Inc.
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Furushiro M
Yakult Central Inst. Microbiological Res. Tokyo Jpn
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