Glycerides Rich in Conjugated Linoleic Acid (CLA) Improve Blood Glucose Control in Diabetic C57BLKS-Lepr^<db>/lepr^<db> Mice

概要

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Although dietary conjugated linoleic acid (CLA) has been shown to have anti-diabetic activity in Zucker diabetic fatty fa/fa rats, the long-term administration of glycerides rich in CLA (TG-CLA) had no effect on diabetic status in C57BLKS-Leprdb/leprdb(db/db) mice. In the present study, the effect of TG-CLA on blood glucose control in diabetic db/db mice was examined. Mice were fed a diet supplemented with either 1.2% safflower oil (control) or 1.2% TG-CLA. Oral glucose tolerance tests (OGTTs) were performed after 5 and 11 weeks of TG-CLA treatment. The body weight, fat pad weight and amounts of food consumed were lower in the TG-CLA fed mice than in the control. The administration of TG-CLA for 5 and 11 weeks suppressed the blood glucose increase after oral glucose ingestion. Furthermore, the insulin level during OGTTs had increased after 5 weeks of treatment, but it was suppressed after 11 weeks. These results that revealed beneficial effects of TG-CLA on blood glucose control in diabetic db/db mice, in addition to improved insulin sensitivity after a transient increase in insulin secretion, indicate the need for further study in human subjects.
日本油化学会の論文
2001-11-01