Enhanced Learning of Normal Adult Rodents by Repeated Oral Administration of Soybean Transphosphatidylated Phosphatidylserine
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概要
- 論文の詳細を見る
Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) is already known to improve the learning ability of aged or drug-induced amnesic rodents. In this study, its effect on normal adult rodents was evaluated using several learning tasks. Firstly, three behavioral tests (open-field, Y-maze, and active avoidance test) were consecutively carried out after the daily oral administration of SB-tPS (50 mg/kg per day, for 34 days). Repeated oral administration of SB-tPS did not affect either exploratory behavior in the open-field test or spontaneous alternation behavior in the Y-maze test, while mice pretreated with SB-tPS showed significant enhancement of conditioned avoidance response. Secondly, the brightness discrimination test was used to evaluate the effect of SB-tPS on learning ability. The daily oral administration of SB-tPS (50 mg/kg per day, for 27 days) to normal rats significantly increased the correct response ratio in the brightness discrimination test. Finally, to elucidate the necessity of SB-tPS pretreatment, another active avoidance test was carried out, and no enhancement of conditioned avoidance response was observed in non-pretreated mice. These results suggest that repeated administration of SB-tPS could enhance the learning ability of normal adult rodents as those of aged ones.
- 社団法人 日本薬理学会の論文
- 2005-07-20
著者
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UKAI Makoto
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University
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Ukai Makoto
Department Of Chemical Pharmacology Faculty Of Pharmacy Meijo University
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Ukai Makoto
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Kudo Satoshi
Yakult Central Institute For Microbiological Research
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SAKAI Masashi
Yakult Central Institute for Microbiological Research
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Kataoka Kato
Yakult Central Institute For Microbiological Research
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KAMEYAMA TSUTOMU
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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Kameyama Tsutomu
Department Of Biology Faculty Of Science Ochanomiz University
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Kameyama Tsutomu
Department Of Chemical Pharmacology Faculty Of Pharmacy Meijo University
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kataoka-Kato Akito
Yakult Central Institute for Microbiological Research
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