Effect of Indole on the Mono-oxygenase System in Rat Liver Microsomes
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概要
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The effect of indole on the mono-oxygenase systems was studied in liver microsomes from control, indole-, phenobarbital-and 3-methylcholanthrene-treated rats. No induction was observed by indole of either cytochrome P-450 or the mono-oxigenase activities. It was, however, a potent competitive inhibitor of aniline hydroxylase (Ki=0.03mM-0.04mM). A spectroscopic study showed that this competition occurred at the aniline binding site on cytochrome P-450. The inhibitory effect was observed on aminopyrine N-demethylase with less efficiency (Ki=0.1-0.5 mM) and on benzo[a]pyrene hydroxylase. These inhibitions were also observed in the systems of mice, rabbits and monkeys. The physiological effect of indole on liver drug metabolism was also discussed.
- 社団法人 日本農芸化学会の論文
著者
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WATANUKI Masaaki
Yakult Central Institute for Microbiological Research
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TOHYAMA Kiyoshi
Yakult Central Institute for Microbiological Research
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SAKAI Masashi
Yakult Central Institute for Microbiological Research
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MUTAI Masahiko
Yakult Central Institute for Microbiological Research
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