The Effects of Soybean Transphosphatidylated Phosphatidylserine on Cholinergic Synaptic Functions of Mice
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概要
- 論文の詳細を見る
The effects of soybean transphosphatidylated phosphatidylserine(SB−tPS)on cholinergic synaptic functions were investigated using cerebral cortical synaptosomes from mice.Treatment of the synaptosomes with SB−tPS increased high K+−induced acetylcholine(ACh)release in a bell−shaped, dose−dependent manner without affecting ACh synthesis.SB−tPS(10 and 50μM)also enhanced synaptosomal synthesis of sn−glycero−3−phosphocholine, but did not affect phosphorylcholine synthesis.In contrast, the choline synthesis was significantly reduced as SB−tPS concentration increased.The present result that SB−tPS modified the cholinergic pathway can partly explain its nootropic functions.
- 社団法人 日本薬理学会の論文
- 2000-09-01
著者
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Kudo Satoshi
Yakult Central Institute For Microbiological Research
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SAKAI Masashi
Yakult Central Institute for Microbiological Research
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YAMATOYA Hideyuki
Yakult Central Institute for Microbiological Research
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Sakai Michinori
Fundamental Research Laboratories Hisamitsu Pharmaceutical Co. Inc.
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Saeki Masakazu
Fundamental Research Laboratories Hisamitsu Pharmaceutical Co. Inc.
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