Inhibitory Effect of Gliotoxin on Platelet Aggregation:- Importance of Disulfide Structure -
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概要
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In the course of screening for anti-platelet principles produced by micro-organisms, strong anti-platelet activity was detected in the culture broth of Aspergillus fumigatus Fres. The purified active compound was identified as gliotoxin. Gliotoxin inhibited ADP-induced aggregation as well as collagen- or arachidonate-induced aggregation of rabbit platelets (IC50 = about 27 μM) and also accelerated the dissociation of aggregates. Gliotoxin also inhibited the heat hemolysis of rabbit erythrocytes, suggesting that this agent is a membrane-stabilizing anti-aggregant. The disulfide structure in the gliotoxin molecule was responsible for the inhibitory activity, because desthiogliotoxin had effects on neither platelet aggregation nor heat hemolysis of erythrocytes.
- 社団法人 日本農芸化学会の論文
著者
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WATANUKI Masaaki
Yakult Central Institute for Microbiological Research
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SAKAI Masashi
Yakult Central Institute for Microbiological Research
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