In vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata.
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概要
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Effect of microinjection of apomorphine into the substantia nigra zona reticulata (SNP, ) on the dopamine (DA) release in the ipsilateral striatum was examined in the present study. To measure the DA release, we determined DA and/or DOPAC levels in the striatum by using in vivo voltammetry. The microinjection of apomorphine (10 μg/2 μl) into the SNR produced a rapid and prolonged increase in the DA and/or DOPAC peak in the ipsilateral striatum. These results suggest that release of DA from dendrites of DA cells normally plays a physiological role in the SNR neurons.
- 公益社団法人 日本薬理学会の論文
著者
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Sugimoto Akira
Department Of Cardiology Saiseikai Ibaraki Hospital
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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SUGIMOTO Akira
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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Sugimoto Akira
Department of Applied Chemistry, College of Engineering, University of Osaka Prefecture
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