A MODE OF ACTION OF MORPHINE ON A QUICKLY LEARNED CONDITIONED SUPPRESSION IN MICE
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概要
- 論文の詳細を見る
Mice exhibited marked suppression of motor activity when placed in the same environment where they had previously received electric shocks. Morphine-HCl (20 mg/kg) markedly attenuated such a conditioned suppression in mice. The morphine-induced reduction of the conditioned suppression was antagonized by pretreatment with reserpine (0.1 and 0.5 mg/kg), haloperiodol, pimozide and α-methyl-p-tyrosine, but not atropine-sulfate, p-chlorophenylalanine, phenoxybenzamine-HCl or propranolol. Thus, it is possible that the potentiation of the dopaminergic neurotransmission in the brain is involved in the morphine-induced reduction of the conditioned suppression in mice.
- 公益社団法人日本薬学会の論文
著者
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Nagasaka Mitsuaki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Kameyama Tsutomu
Department Of Biology Faculty Of Science Ochanomiz University
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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