Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring

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概要

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• The effects of prenatal administration of phencyclidine (PCP) on the learning and memory processes of rat offspring were investigated at doses below the level for producing malformations. The offspring prenatally treated with PCP (10 or 20 mg/kg) on days 7 to 17,as well as on days 7 to 21 of gestation, showed disruption of the acquisition of passive avoidance response and pole-climbing avoidance response at the ages of 4 and 7 weeks, respectively. The brain weight of the offspring prenatally treated with PCP was significantly decreased. These results suggest that prenatal PCP administration impairs learning and memory processes of passive and active avoidance tasks and that more attention should be given to the developmental toxicity of PCP.

• 公益社団法人日本薬学会の論文

著者

• FURUKAWA Hiroshi

  Faculty of Pharmacy, Meijo University

• Ogawa S

  Nagoya Univ. Nagoya Jpn

• 加藤 明良

  Seikei Univ. Musashino Jpn

• Nabeshima Toshitaka

  Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med

• Nabeshima Toshitaka

  Faculty Of Pharmaceutical Sciences Meijo University

• Furukawa Hiroshi

  Faculty Of Pharmacy Meijo University

• KAMEYAMA TSUTOMU

  Faculty of Pharmaceutical Sciences, Meijo University

• Katoh Akira

  Faculty of Engineering, Seikei University

• 加藤 明良

  成蹊大学 工学部 応用化学科

• Kameyama Tsutomu

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Furukawa Hiroshi

  Dept. Chemical Pharmacology Fac. Of Pharmaceut. Sci. Meijo Univ.

• HIRAMATSU Masayuki

  Faculty of Pharmaceutical Sciences, Meijo University

• YAMAGUCHI Kazumasa

  Faculty of Pharmaceutical Sciences, Miijo University

• KASUGAI Masami

  Faculty of Pharmaceutical Sciences, Meijo University

• ISHIZAKI Kimie

  Faculty of Pharmaceutical Sciences, Meijo University

• KAWASHIMA Kazuaki

  Faculty of Pharmaceutical Sciences, Meijo University

• ITOH Kaname

  Faculty of Pharmaceutical Sciences, Meijo University

• OGAWA Shinichi

  Faculty of Pharmaceutical Sciences, Meijo University

• Itoh Kaname

  Faculty Of Pharmaceutical Sciences Meijo University

• Ishizaki Kimie

  Faculty Of Pharmaceutical Sciences Meijo University

• Kasugai Masami

  Faculty Of Pharmaceutical Sciences Meijo University

• Kameyama Tsutomu

  Faculty Of Pharmaceutical Sciences Meijo University

• Kameyama T

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University

• Kawashima Kazuaki

  Faculty Of Pharmaceutical Sciences Meijo University

• Yamaguchi Kazumasa

  Faculty Of Pharmaceutical Sciences Miijo University

• Nabeshima Toshitaka

  Dept. Of Neuropsychopharmacol. & Hosp. Pharm. Nagoya U. Sch. Of Med.

• Nabeshima Toshitaka

  Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med

• Kameyama Tsutomu

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University

• Kameyama Tsutomu

  Dept. Of Chem. Pharmaco. Meijo Univ.

• Nabeshima Toshitaka

  Department Of Hospital Pharmacy School Of Medicine Nagoya University

• Furukawa Hiroshi

  Faculty Of Health Sciences Kobe University School Of Medicine

• Furukawa Hiroshi

  Faculty Of Computer Science And Systems Engineering Kyushu Institute Of Technology

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