Microbial Growth-Promotion Activity of 3-Hydroxymonoazine- and N-Hydroxydiazine-Type Heterocycles
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概要
- 論文の詳細を見る
Three 3-hydroxymonoazine- and three N-hydroxydiazine-type heterocycles were tested whether they act as artificial siderophores toward Aureobacteriumfiavescens JG-9 (ATCC No. 25091). Among them, 1-hydroxy-3,5,6-trimethyl-2 (1H)-pyrazinone (3) showed the highest growth-promotion activity comparable to desferrioxamine B (DFB), a natural trihydroxamate siderophore, at 48.5 μM or above, followed by 1-hydroxy-5,6-dimethyl-2(1H)-pyrazinone (2), 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone (1), and 3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinone (6), while 3-hydroxy-1 ,2-dimethyl-4 (1H) -pyridinone (5) did not show the bioactivity. These results are the first examples of N-hydroxydiazine-type heterocycles acting as artificial siderophores for A. flavescens JG-9.
- 社団法人日本薬学会の論文
- 2002-09-01
著者
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原田 和雄
東学大・教・生命
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齋藤 良太
Department of Applied Chemistry, Faculty of Engineering, Seikei University
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Ghosh Kallol
Department of Applied Chemistry, Faculty of Engineering, Seikei University
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原田 和雄
Department of Life Science, Tokyo Gakugei University
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加藤 明良
Department of Applied Chemistry, Faculty of Engineering, Seikei University
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加藤 明良
Seikei Univ. Musashino Jpn
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Ghosh Kallol
Department Of Applied Chemistry Faculty Of Engineering Seikei University
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加藤 明良
成蹊大学工学部工業化学科
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加藤 明良
成蹊大学 工学部 応用化学科
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Ghosh Kallol
Seikei Univ. Tokyo
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