Dimroth-Type Ring Transformation of 1,4,6-Trisubstituted-2 (1H)-Pyrimidinethiones with Ammonia and Primary Alkyl Amines

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概要

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• 1,4,6-Trisubstituted 2 (1H)-pyrimidinethiones (Ia-k) underwent Dimroth-type ring transformation with ammonia and primary alkyl amines in the presence of silver perchlorate to afford 2-(N-substituted) aminopyrimidines (IIa, c, d, f, j, k) and pyrimidinium perchlorates (IIIa-c, e-j), respectively. Furthermore, pyrimidinium perchlorates (III) were converted into 2 (1H)-pyrimidinones (IV) in high yields by hydrolysis with concentrated hydrochloric acid.

• 公益社団法人日本薬学会の論文
• 1982-06-25

著者

• 加藤 明良

  Department of Applied Chemistry, Faculty of Engineering, Seikei University

• 横田 祐子

  Department Of Chemistry University Of Tsukuba

• 鹿島 長次

  Department of Chemistry, University of Tsukuba

• 表 美守

  Department of Chemistry, University of Tsukuba

• 表 美守

  Department Of Chemistry University Of Tsukuba

• 鹿島 長次

  筑波大学化学系

• 鹿島 長次

  Department Of Chemistry University Of Tsukuba

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• Dimroth-Type Ring Transformation of 1,4,6-Trisubstituted-2 (1H)-Pyrimidinethiones with Ammonia and Primary Alkyl Amines
• Ring Transformation Reaction of 1,4,6-Trisubstituted 2 (1H)-Pyrimidinones and -Thiones with Hydroxylamine
• Synthesis of 2(1H)-Pyrimidinone-Containing α-Amino Acid Derivatives by Chemical Modification of L-Glutamic Acid
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