Ring Transformation Reaction of 1,4,6-Trisubstituted 2 (1H)-Pyrimidinones and -Thiones with Hydroxylamine

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概要

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• 1,4,6-Trisubstituted 2 (1H)-pyrimidinones (Ia-e) underwent ring transformation with hydroxylamine to afford 3,5-disubstituted isoxazoles (IIa-e) in high yields. On the other hand, 2 (1H)-pyrimidinethiones (IIIa, b, f-k) underwent ring transformation to give mainly a new type of N-substituted 2-aminopyrimidine 1-oxides (IVa, b, f-k) as well as isoxazoles. The reaction of pyrimidinium salts (VII, VIII and IX) with hydroxylamine is also discussed.

• 公益社団法人日本薬学会の論文
• 1981-09-25

著者

• 加藤 明良

  Department of Applied Chemistry, Faculty of Engineering, Seikei University

• 横田 祐子

  Department Of Chemistry University Of Tsukuba

• 鹿島 長次

  Department of Chemistry, University of Tsukuba

• 表 美守

  Department of Chemistry, University of Tsukuba

• 表 美守

  Department Of Chemistry University Of Tsukuba

• 鹿島 長次

  筑波大学化学系

• 鹿島 長次

  Department Of Chemistry University Of Tsukuba

関連論文

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• Studies on 1-(2-Phenethyl)-4-(N-propionylanilino)piperidine (Fentanyl) and Related Compounds. I. Spectrometric and Chromatographic Analyses of 3-Methylfentanyl and α-Methylfentanyl
• Dimroth-Type Ring Transformation of 1,4,6-Trisubstituted-2 (1H)-Pyrimidinethiones with Ammonia and Primary Alkyl Amines
• Ring Transformation Reaction of 1,4,6-Trisubstituted 2 (1H)-Pyrimidinones and -Thiones with Hydroxylamine
• Synthesis of 2(1H)-Pyrimidinone-Containing α-Amino Acid Derivatives by Chemical Modification of L-Glutamic Acid
• Ring Transformation Reactions of 1-Substituted 2 (1H)-Pyrimidinones and Related Compounds with Active Methylene Compounds
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