Ring Transformation Reactions of 1-Substituted 2 (1H)-Pyrimidinones and Related Compounds with Active Methylene Compounds

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概要

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• 1-Substituted 2 (1H)-pyrimidinones (I) underwent ring transformation with malononitrile and ethyl acetoacetate in the presence of sodium ethoxide to give 2-amino-3-pyridinecarbonitriles (II-VII) and N-(substituted) amino-3-pyridinecarboxylic acids (XIV and XV), respectively. Further, I reacted with ethyl cyanoacetate, dialkyl malonate, or ethyl benzoylacetate to give pyridine derivatives (VIII-XIII) bearing various functional groups at the C-3 position. The reaction of 1-substituted 2 (1H)-pyrimidinethiones and 4,6-dimethyl-1-phenyl-2-phenylimino-1,2-dihydropyrimidine with active methylene compounds is also discussed.

• 公益社団法人日本薬学会の論文
• 1984-08-25

著者

• 鹿島 長次

  Department of Chemistry, University of Tsukuba

• 表 美守

  Department of Chemistry, University of Tsukuba

• 表 美守

  Department Of Chemistry University Of Tsukuba

• 鹿島 長次

  筑波大学化学系

• 鹿島 長次

  Department Of Chemistry University Of Tsukuba

関連論文

• Studies on 1-(2-Phenethyl)-4-(N-propionylanilino)piperidine (Fentanyl) and Related Compounds. I. Spectrometric and Chromatographic Analyses of 3-Methylfentanyl and α-Methylfentanyl
• Dimroth-Type Ring Transformation of 1,4,6-Trisubstituted-2 (1H)-Pyrimidinethiones with Ammonia and Primary Alkyl Amines
• Ring Transformation Reaction of 1,4,6-Trisubstituted 2 (1H)-Pyrimidinones and -Thiones with Hydroxylamine
• Ring Transformation Reactions of 1-Substituted 2 (1H)-Pyrimidinones and Related Compounds with Active Methylene Compounds
• 2(1H)-ピリミジノン類およびその塩の抗炎症作用
• The [4+2] Cycloaddition of 1,6-Dihydro-2-dimethylamino-4,6,6-trimethylpyrimidine with Acetylenic Compounds(Organic,Chemical)
• ルミノ-ル類の光酸化反応
• 筑波大学における基礎および一般化学教育(大学における基礎および一般化学教育)
• β-アミノエノン化合物の化学
• アゾール類のオゾン分解とその有機合成への応用
• 1-(オルト置換フェニル)-2(1H)-ピリミジンチオン類の位置選択的ヒドリド還元におけるオルト置換基の効果 (ヘテロ原子の有機化学) -- (5族元素(窒素,リン,アンチモン))
• β-イミダゾリルエノン類の合成と反応

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