Basic and Translational Research on Proteinase-Activated Receptors : Regulation of Nicotine Reward by the Tissue Plasminogen Activator (tPA) : Plasmin System via Proteinase-Activated Receptor 1
スポンサーリンク
概要
- 論文の詳細を見る
Nicotine, a primary component of tobacco, is one of the most abused drugs worldwide. Mesolimbic dopaminergic neurons mediate the rewarding effects of abused drugs, including nicotine. We show that the tissue plasminogen activator (tPA) – plasmin system regulates nicotine-induced reward and dopamine release in the nucleus accumbens (NAc) by activating proteinase-activated receptor 1 (PAR1). Nicotine-induced conditioned place preference and dopamine release in the NAc are diminished in tPA knockout (tPA−/−) mice. The defect of nicotine-induced dopamine release in tPA−/− mice is reversed by microinjection of either exogenous tPA or plasmin into the NAc. Acute nicotine treatment increases tPA protein levels and promoted the release of tPA into the extracellular space. The expression of PAR1 on dopaminergic neurons is evident and the activation of PAR1 by plasmin is demonstrated by assaying GTP-γS binding. Finally, nicotine-induced conditioned place preference and dopamine release are diminished in PAR1−/− mice. These findings suggest that targeting the tPA-plasmin–PAR1 system would provide new therapeutic approaches for the treatment of nicotine dependence.
- 社団法人 日本薬理学会の論文
- 2008-12-20
著者
-
YAMADA Kiyofumi
Department of Neurosurgery, Graduate School of Medicine, Gifu University
-
Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
-
Yamada Kiyofumi
Department Of Hospital Pharmacy Nagoya University School Of Medicine
-
Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
-
Nagai Taku
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Nagai Taku
Department Of Biochemistry And Molecular Pathophysiology University Of Occupational And Environmenta
-
Yamada Kiyomi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Yamada Kiyofumi
Dept. Of Neuropsychopharmacol. & Hosp. Pharm. Nagoya U. Sch. Of Med.
-
Nabeshima Toshitaka
Dept. Of Neuropsychopharmacol. & Hosp. Pharm. Nagoya U. Sch. Of Med.
-
Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Nabeshima Toshitaka
Department Of Hospital Pharmacy Nagoya University School Of Medicine
-
Nagai Taku
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Nabeshima Toshitaka
Department Of Hospital Pharmacy School Of Medicine Nagoya University
関連論文
- Growth Hormone-Releaser Diet Attenuates β-Amyloid(1-42)-Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice
- Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor
- Convulsion During Intra-arterial Infusion of Fasudil Hydrochloride for the Treatment of Cerebral Vasospasm Following Subarachnoid Hemorrhage
- Effects of Dietary Vegetable Oils on Behavior and Drug Responses in Mice
- 22B-10-4 Analysis of morphine dependence mechanism using cyclic AMP responsive element binding protein binding protein (CBP) mutation mice.
- A-5 EFFECT OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) ON STEREOTYPED BEHAVIORS AND NEUROTRANSMITTER RELEASE INTO RAT BRAIN DIALYSATE IN VIVO
- 高カロリー輸液施行時の家兎における酸代謝に対する塩酸および酢酸の影響
- Neuropsychotoxicity of Abused Drugs : Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects
- Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D_1-Like Receptors
- Growth Hormone Releaser Attenuates β-Amyloid (1-42)-Induced Memory Impairment in Mice
- PAP 9704, a Korean Herbal Medicine Attenuates Methamphetamine-Induced Hyperlocomotion via Adenosine A_ Receptor Stimulation in Mice(Pharmacology)
- Effect of Dietary Fiber on Morphine-induced Constipation in Rats(Food & Nutrition Science)
- Superficial Temporal Artery to Middle Cerebral Artery Double Bypass Via a Small Craniotomy : —Technical Note—
- Evaluation of Interleukin-2 mRNA in Whole Blood as a Parameter for Monitoring Cyclosporine Pharmacodynamics(Pharmacology)
- Time-dependent Effects of Klebsiella pneumoniae Endotoxin on Hepatic Drug-metabolizing Enzyme Activity in Rats.
- Granulocyte Colony-Stimulating Factor Enhances Endotoxin-Induced Decrease in Biliary Excretion of the Antibiotic Cefoperazone in Rats.
- Angioplasty and Stenting of Totally Occluded Common Carotid Artery at the Chronic Stage : Case Report
- Possible Mechanism by Which the Carbapenem Antibiotic Panipenem Decreases the Concentration of Valproic Acid in Plasma in Rats.
- Effects of Metrifonate on Memory Impairment and Cholinergic Dysfunction in Rats.
- Orally Active NGF Synthesis Stimulators : Potential Therapeutic Agents in Alzheimer's Disease.
- Effects of Metrifonate on Impairment of Learning and Dysfunction of Cholinergic Neuronal System in Basal Forebrain-lesioned Rats.
- Oral Administration of Propentofylline, a Stimulator of Nerve Growth Factor(NGF) Synthesis, Recovers Cholinergic Neuronal Dysfunction Induced by the Infusion of Anti-NGF Antibody into the Rat Septum.
- Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration.
- Structure-Related Pharmacokinetics of Xanthines after Direct Administration into the Peritoneal Cavity of Rats
- Age-Related Changes in Learning and Memory and Cholinergic Neuronal Function in Senescence Accelerated Mice (SAM).
- DESIGN OF A PHENCYCLIDINE IMPLANTATION PELLET : SUITABLE FOR TOLERANCE DEVELOPMENT
- MECHANISM OF TOLERANCE DEVELOPMENT TO PHENCYCLIDINE IN RELATION TO GABA-ERGIC NEURONAL AND DISPOSITIONAL FUNCTIONS IN MICE
- Molecular Mechanism of Cholinergic Dysfunction and Cognitive Deficits Induced by Amyloid β-Peptide
- Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity
- Neuropsychotoxicity of Abused Drugs : Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents
- Tissue Plasminogen Activator (t-PA) Is Involved in Morphine-Induced Rewarding Effects
- Superficial Temporal Artery to Middle Cerebral Artery Double Bypass Via a Small Craniotomy : Technical Note
- The role of N-methyl-D-aspartate receptors in development of morphine dependence in mice (NEREVOUS SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Comparative Absorption of 5-Aminosalicylic Acid(5-ASA)after Administration of a 5-ASA Enema and Salazosulfapyridine(SASP)after an SASP Suppository in Japanese Volunteers
- Dysfunction of Cholinergic and Dopaminergic Neuronal System in β-Amyloid Protein- Infused Rats.
- Propentofylline Prevents Neuronal Dysfunction Induced by Infusion of Anti-Nerve Growth Factor Antibody into the rat Septum.
- Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats.
- Nerve growth factor content in rat brains increases following basal-forebrain lesions induced by ibotenic acid, but not by electrolysis.
- Development of Plasticity of Brain Function with Repeated Trainings and Passage of Time after Basal Forebrain Lesions in Rats.
- Memory Impairment and Neural Dysfunction after Continuous Infusion of Anti-Nerve Growth Factor Antibody into the Septum in Adult Rats.
- Effects of Oral Administration of a Stimulator for Nerve Growth Factor Synthesis in Basal Forebrain-Lesioned Rats.
- Denervation of Dopaminergic Neurons with 6-Hydroxydopamine Increases Nerve Growth Factor Content in Rat Brain.
- DOSE-DEPENDENT PHARMACOKINETICS OF ENPROFYLLINE IN RATS
- The Roles of Glial Cell Line-Derived Neurotrophic Factor, Tumor Necrosis Factor-α, and an Inducer of These Factors in Drug Dependence
- Prophylaxis of Local Vascular Graft Infection with Levofloxacin Incorporated into Albumin-Sealed Dacron Graft (LVFX-ALB Graft)
- Prevention of Vascular Graft Infection by Sisomicin Incorporated into Fibrin Glue
- Effects of Nicotine on Stress Response in Mice
- DEVELOPMENT OF AMNESIA MODEL FOR SCREENING OF NOOTROPIC DRUGS AND EFFECTS OF MEVALONIC-GABA ON LEARNING AND MEMORY IN MICE
- Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats
- S5-4 Psychobehavioral deficits induced by a non-competitive N-methyl-D-aspartate receptor antagonist and signal transduction through N-methyl-D-aspartate receptors(SYMPOSIUM 5: PHYSIOLOGY AND DISEASE OF GLUTAMATE IN NEURONAL AND GLIAL CELLS)(Proceedings o
- Elimination Kinetics of Quinaprilat and Perindoprilat in Hypertensive Patients with Renal Failure on Haemodialysis
- Conditioned Suppression of Motility : Possibility for Evaluation of Learning and Memory in Mice
- TOXICITY OF β-AMYLOID PEPTIDE
- Difference in Toxicity of β-Amyloid Peptide with Aging in Relation to Nerve Growth Factor Content in Rat Brain.
- Impairments of Long-term Potentiation in Hippocampal Slices of Beta-amyloid-infused Rats.
- NGF Level Is Not Decreased in the Serum, Brain-Spinal Fluid, Hippocampus, or Parietal Cortex of Individuals with Alzheimer's Disease.
- Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring
- DOPAMINERGIC INVOLVEMENT IN PHENCYCLIDINE-INDUCED STEREOTYPED BEHAVIOR
- Perspectives of Pharmacotherapy in Alzheimer's Disease
- A survey of antipsychotic polypharmacy in outpatients at Nagoya University Hospital
- The Necessity of Adjusting the Dosage of Zonisamide When Coadministered with Other Anti-epileptic Drugs
- Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice : Involvements of 5-HT_ Receptor
- Basic and Translational Research on Proteinase-Activated Receptors : Regulation of Nicotine Reward by the Tissue Plasminogen Activator (tPA) : Plasmin System via Proteinase-Activated Receptor 1
- Drug Dependence, Synaptic Plasticity, and Tissue Plasminogen Activator
- Up-regulation of cAMP, but not voltage-sensitive calcium ion channels is involved in the inhibitory effects of nefiracetam on methamphetamine-induced discriminative responses
- Changes in Ciliary Neurotrophic Factor Content in the Rat Brain after Continuous Intracerebroventricular Infusion of β-Amyloid(1-40)Protein
- Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody.
- IMPAIRMENT OF ACTIVE AVOIDANCE RESPONSE IN RATS WITH CONTINUOUS INFUSION OF QUINOLINIC ACID INTO THE LATERAL VENTRICLE
- Recovery and Maintenance of Copper Levels in Geriatric Patients on Enteral Feeding for a Prolonged Period
- EFFECTS OF CATECHOLAMINERGIC OR TRYPTAMINERGIC AGENTS ON THE MORPHINE-INDUCED STRAUB TAIL REACTION
- An Environmental and Biological Study of Occupational Exposure to Cyclophosphamide in the Pharmacy of a Japanese Community Hospital Designated for the Treatment of Cancer
- Memory Impairment and Morphological Changes in Rats Induced by Active Fragment of Anti-nerve Growth Factor-antibody.
- Aged-Related Changes in Learning and Memory, Choline Acetyltransferase Activity and Number of Neuronal Cells in Rats
- Amyloid Pathology and Protein Kinase C (PKC) : Possible Therapeutics Effects of PKC Activators
- Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory Processes
- Endogenous Modulators for Drug Dependence
- Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions.
- CONDITIONED SUPPRESSION AND OPIOID KAPPA RECEPTOR IN MICE
- Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs
- Role of Catecholaminergic and Cyclic AMP Systems in Psychological Dependence on Phencyclidine: A Study in Mutant Mice
- Skin Tests of a Novel Nicotine Patch, PHK-301p, in Healthy Male Volunteers : Phase I, Placebo-Controlled Study
- S9-2 Anti-addictive and pro-addictive substances commonly involved in methamphetamine and morphine dependence(SYMPOSIUM 9: MOLECULAR MECHANISMS OF DRUG DEPENDENCE)(Proceedings of the 31st Annual Meeting)
- PRO-ADDICTIVE AND ANTI-ADDICTIVE FACTORS FOR DRUG DEPENDENCE
- OTOTOXICITY INDUCED BY PRE-AND POSTNATAL EXPOSURE TO AMINOGLYCOSIDE ANTIBIOTICS
- NEUROTOXICITY OF CARBON MONOXIDE IN CENTRAL NERVOUS SYSTEM
- The High Atherosclerotic Risk Among Epileptics : the Atheroprotective Role of Multivitamins
- ROLE OF DOPAMINERGIC AND SEROTONERGIC NEURONAL SYSTEMS IN THE PREFRONTAL CORTEX OF RATS IN PHENCYCLIDINE-INDUCED BEHAVIORS
- ROLE OF DOPAMINERGIC AND GABAERGIC MECHANISMS IN DISCRETE BRAIN AREAS IN PHENCYCLIDINE-INDUCED LOCOMOTOR STIMULATION AND TURNING BEHAVIOR
- INVOLVEMENT OF OPIOID RECEPTORS IN HYPO- AND HYPER-THERMIC EFFECTS INDUCED BY PHENCYCLIDINE IN MICE
- EFFECTS OF DIFENAMIZOLE ON CONTENT OF CATECHOLAMINES AND METABOLITES IN MOUSE BRAIN
- Two pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo
- CORRELATION BETWEEN THE 5-HYDROXYTRYPTAMINE CONTENTS IN THE BRAIN AND DEGREES OF SENSORY, AND LOCOMOTOR ACTIVITIES IN THE RAT
- Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (2): Changes in GABAA and Benzodiazepine Receptor Binding
- D-Serine Ameliorates Neonatal PolyI:C Treatment–Induced Emotional and Cognitive Impairments in Adult Mice
- Reliability and Validity of the Japanese Version of BEMIB Modified for Patients With Bipolar Disorder: a Self-rating Scale for Medication Adherence
- Animal Model for Schizophrenia That Reflects Gene-Environment Interactions
- Effects of Risperidone on Phencyclidine-Induced Behaviors: Comparison with Haloperidol and Ritanserin.
- Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the (3H)QNB Binding.
- Neuropharmacological Characterization of Voltage-Sensitive Calcium Channels: Possible Existence of Neomycin-Sensitive, .OMEGA.-Conotoxin GVIA- and Dihydropyridines-Resistant Calcium Channels in the Rat Brain.
- D-Serine Ameliorates Neonatal PolyI:C Treatment-Induced Emotional and Cognitive Impairments in Adult Mice