Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor
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概要
- 論文の詳細を見る
Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT1A–receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A–agonist activity in a 8-OH-DPAT–stimulated [35S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.
著者
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SHIN Eun-Joo
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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KIM Hyoung-Chun
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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YAMADA Kiyofumi
Department of Neurosurgery, Graduate School of Medicine, Gifu University
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Whang Wan
Phamaceutical Resources Botany, College of Pharmacy, Chung-Ang University, Korea
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Kim Sungun
Phamaceutical Resources Botany, College of Pharmacy, Chung-Ang University, Korea
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Bach Jae-Hyung
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Ko
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Kim Jin-Man
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Ko
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Nguyen Xuan-Khanh
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Ko
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Nguyen Thuy-Ty
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Ko
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Jung Bae
School of Veterinary Medicine, Kangwon National University, Korea
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Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
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Kim Hyoung-chun
Neuropsychopharmacology And Toxicology Program Coll. Of Pharmacy Kangwon National Univ.
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Yamada Kiyofumi
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Jung Bae
School Of Veterinary Medicine Kangwon National University
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Nguyen Xuan-khanh
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Nguyen Thuy-ty
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Kim Sun
Phamaceutical Resources Botany College Of Pharmacy Chung-ang University
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Kim Jin-man
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Whang Wan
Phamaceutical Resources Botany College Of Pharmacy Chung-ang University
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Shin Eun-joo
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Bach Jae-hyung
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Nguyen Thuy-Ty
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea
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Nguyen Xuan-Khanh
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea
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Bach Jae-Hyung
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea
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Kim Jin-Man
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea
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Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Japan
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Shin Eun-Joo
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Korea
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