Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats : Possible Involvement of an Impaired Synaptic Transmission to the 5-HT_<2A> Receptor
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概要
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Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague–Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains.
- 2009-07-20
著者
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SHIN Eun-Joo
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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JEONG Ji
Department of Pharmacology, Chung-Ang University
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CHUNG Yoon
Department of Anatomy, College of Medicine, Chung-Ang University
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KIM Tae-Woo
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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SHIN Chan
Department of Pharmacology, School of Medicine, Konkuk University
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KIM Won-Ki
Department of Neuroscience, School of Medicine, Korea University
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KO Kwang-Ho
Department of Pharmacology, College of Pharmacy, Seoul National University
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KIM Hyoung-Chun
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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Kim Hyoung-chun
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Kim Won-ki
Department Of Neuroscience School Of Medicine Korea University
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Shin Chan
Department Of Internal Medicine Seoul National University College Of Medicine
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Chung Yoon
Department Of Anatomy College Of Medicine Chung-ang University
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Shin Chan
Department Of Pharmacology School Of Medicine Konkuk University
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Kim Hyoung-chun
Neuropsychopharmacology And Toxicology Program Coll. Of Pharmacy Kangwon National Univ.
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Kim Hyoung-chun
Neuropsychopharmacology And Toxicology Program Coll. Of Pharmacy Kangwon National Univ. Kor
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Jhoo Jin
Department Of Pharmacology Chung-ang University
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Kim Tae-woo
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Ko Kwang
韓国
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Shin Eun-joo
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Jeong Ji
Department Of Pharmacology College Of Medicine Chung-ang University
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Kim Won-ki
Department Of Energy Systems Engineering Seoul National University
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Jeong Ji
Department of Pathology, Kyungpook National University Medical Center, 474 Hakjeongdong, Buk-gu, Daegu 702-210, Republic of Korea
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