Growth Hormone Releaser Attenuates β-Amyloid (1-42)-Induced Memory Impairment in Mice

概要

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Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimers disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1 – 42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1 – 42).
社団法人日本薬理学会の論文
2005-09-20