Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs

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概要

• 論文の詳細を見る

• Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.

• 社団法人 日本薬理学会の論文

著者

• SHIN Eun-Joo

  Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University

• Bach Jae-Hyung

  Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Ko

• Kim Hyoung-chun

  Neuropsychopharmacology And Toxicology Program Coll. Of Pharmacy Kangwon National Univ.

• Nabeshima Toshitaka

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University

• Lee Sung

  Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Ko

• Kim Jeong

  Central Research Center, Green Cross Corp, Korea

• Lee Jinhwa

  Central Research Center, Green Cross Corp, Korea

• Hong Jau-Shyong

  Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environme

• Kim Jeong

  Central Res. Center Green Cross Corp Kor

• Hong Jau-shyong

  Neuropharmacology Section Lab. Of Pharmacology And Chemistry National Inst. Of Environmental Health

• Shin Eun-joo

  Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University

• Lee Jinhwa

  Central Research Center Green Cross Corp

• Bach Jae-hyung

  Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University

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