Neuropsychotoxicity of Abused Drugs : Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects
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概要
- 論文の詳細を見る
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulating evidence suggests that metabolism to phencyclidine-like dextrorphan is not essential for the neuroprotective activity of dextromethorphan. Here, we review the neuroprotective properties of dextromethorphan and its potential for abuse and the potential neuroprotective effects of the drug’s analogs and 3-hydroxymorphinan, a metabolite of dextromethorphan. These compounds may provide a novel therapeutic direction for the treatment of neurodegenerative diseases such as convulsive or parkinsonian-like disorders.
- 社団法人 日本薬理学会の論文
- 2008-01-20
著者
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SHIN Eun-Joo
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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KIM Hyoung-Chun
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
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Kim Hyoung-chun
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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Kim Hyoung-chun
Neuropsychopharmacology And Toxicology Program Coll. Of Pharmacy Kangwon National Univ.
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Kim Hyoung-chun
Neuropsychopharmacology And Toxicology Program Coll. Of Pharmacy Kangwon National Univ. Kor
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LEE Phil
Department of Chemistry, Kangwon National University
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KIM Hyun
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Meijo University
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Lee Phil
Department Of Chemistry Kangwon National University
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Lee Phil
Department Of Chemistry College Of Natural Sciences Kangwon National University
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Shin Eun-joo
Neuropsychopharmacology And Toxicology Program College Of Pharmacy Kangwon National University
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