Effects of Nerve Growth Factor(NGF) in Rats with Basal Forebrain Lesions.
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概要
- 論文の詳細を見る
Effects of nerve growth factor (NGF)on the basal forebrain (BF)lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT)activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.
- 公益社団法人 日本薬理学会の論文
著者
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Hayashi Kyozo
Department Of Biochemistry Osaka University Of Pharmaceutical Sciences
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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NABESHIMA Toshitaka
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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Ogawa Shin-ichi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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