Some Properties of Metallothioneins from Hepato-pancreas and Kidney in Carp (Cyprinus carpio)
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概要
- 論文の詳細を見る
Carp (Cyprinus carpio) were injected intraperitoneally with 2 mg Cd/kg body weight as CdCl_2 solution. Two types of isometallothioneins were separated from carp kidney by successive treatment with homogenization, ultracentrifugation, incubation, centrifugation, gel filtration and ion exchange chromatography. Purity was shown by polyacrylamide DISC-gel electrophoresis. The molecular weight of native metallothionein-I and -II was found to be 12000-13000. The disappearance of Cd-mercaptide bond was estimated under acidic conditions. Cysteic residues were about 30% in kidney isometallothioneins, Gly and Lys were high, but no aromatic amino acids or His residues were detected. In a double diffusion test, spur formation was shown between two hepato-pancreatic isometallothioneins, and also between hepato-pancreatic metallothionein-II and kidney metallothionein-II.
- 社団法人日本薬学会の論文
- 1984-06-30
著者
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NAGASE Hisamitsu
Department of Hygienics., Gifu Pharmaceutical University
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Nagase Hisamitsu
Lab. Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical Univ.
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SATO TAKAHIKO
Department of Public Health, Gifu Pharmaceutical University
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KITO HIDEAKI
Department of Public Health, Gifu Pharmaceutical University
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HAYASHI KYOZO
Department of Biology, Gifu Pharmaceutical University
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OSE YOUKI
Department of Environmental Hygiene, Gifu College of Pharmacy
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YONEZAWA SYOJI
Nagoya City Health Research Institute
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ISHIKAWA TETSUYA
Gifu Women's Junior College
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Nagase Hisamitsu
Department Of Hygienics Gifu Pharmaceutical University
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Hayashi Kyozo
Department Of Biochemistry Osaka University Of Pharmaceutical Sciences
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Kito Hideaki
Department Of Hygienics Gifu Pharmaceutical University
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