IMMUNOHISTOCHEMICAL LOCALIZATION OF HUMAN EPIDERMAL GROWTH FACTOR/γ-UROGASTRONE IN SUBMANDIBULAR GLANDS AND IN THEIR OBSTRUCTIVE LESIONS
スポンサーリンク
概要
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Immunohistochemically detectable human epidermal growth factor (hEGF)/γ-urogastrone (γ-UG) was demonstrated with the use of polyclonal anti-hEGF/γ-UG antiserum in normal human submandibular glands and in their obstructive lesions. hEGF/γ-UG was isolated and purified from human urine and tested for its biological specificity by radioreceptor assay, and prepared anti-hEGF Fab' fraction. Histochemical expression of hEGF/γ-UG was confined to the intercalated and striated duct cells, and staining intensities differed depending on the fixations used. PLP fixed frozen sections showed the highest staining for hEGF/γ-UG in ductal segments, and 10% formalin and/or Bouin's fixed paraffin sections also revealed moderate-to-strong deposition. No immunoreactive hEGF/γ-UG was detected in either serous or mucous acinar compartments. In specimens of the obstructive sialoadenitis, hEGF/r-UG staining of degenerated ductal epithelia was reduced, and was completely negative in fully degenerated cells.
- 日本組織細胞化学会の論文
著者
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MORI Masahiko
Department of Oral Pathology, Osaka Dental University
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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Mori M
Asahi Univ. School Of Dentistry Gifu
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TATEMOTO YUKIHIRO
Department of Oral and Maxillofacial Surgery, Kochi Medical School
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TSUKITANI KOUJI
Department of Dentistry, Kyoto Prefectural University of Medicine
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OOSUMI HIROYUKI
Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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KOBAYASHI KAZUMITU
Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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KUROBE MASAYUKI
Department of Biology, Gifu Pharmaceutical University
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HAYASHI KYOZO
Department of Biology, Gifu Pharmaceutical University
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Hayashi Kyozo
Department Of Biochemistry Osaka University Of Pharmaceutical Sciences
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Mori Masahiko
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Mori Masahiko
Department Of Applied Chemistry Faculy Of Engineering And High Technology Research Center Kansai Uni
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