MONOCLONAL ANTIBODY TO KERATIN K8.12 EXPRESSION IN DUCTAL BASAL CELLS OF OBSTRUCTIVE LESIONS AND IN OUTER TUMOR CELLS OF SALIVARY PLEOMORPHIC ADENOMAS
スポンサーリンク
概要
- 論文の詳細を見る
Monoclonal antibody for keratin K8.12 (keratin nos. 13 and 16) was evaluated in paraffin sections of 17 cases of obstructive sialadenitis and 97 pleomorphic adenomas. In normal salivary glands fixed with 10% formalin, K8.12 staining was strongly limited to ductal basal cells, and staining to PKK1 and KL1 was positive in duct cells. Monoclonal antibodies PKK1 and KL1 were compared induct-like structures of obstructive lesions and pleomorphic adenomas. Duct-like structures in obstructive lesions showed strong staining for K8.12 in ductal basal cells, and positive staining for PKK1 and KL1 in ductal epithelial cells, in different stages of ductal obstruction. Pleomorphic adenomas showed an intense expression for K8.12 staining in outer tumor cells of tubulo-ductal structures, and positive reaction for PKK1 and KL1 in luminal tumor cells. The histogenesis of pleomorphic adenoma is discussed in terms of the immunohistochemical labelling of the 3 types of monoclonal antibodies to keratin. The identification of a progenitor cell to ductal basal cells is also hypothesized.
- 日本組織細胞化学会の論文
著者
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TAKAI Yoshiaki
Department of Electronics Engineering, Nagoya University
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Tanaka Takaaki
Department of Materials Science and Technology, Niigata University
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MORI Masahiko
Department of Oral Pathology, Osaka Dental University
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Mori M
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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Yamada K
Department Of Anatomy School Of Health Sciences Fujita Health University
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Yamada Keiki
Dept. Anat. Sch. Hygiene Fujita-gakuen Univ.
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Yamada K
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry:department Of Oral
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Takai Y
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry
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Takai Yoshiaki
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Mori M
Department Of Oral And Maxillofacial Surgery School Of Dentistry Asahi University
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Mori M
Department Of Oral Surgery Asahi University School Of Dentistry
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YAMADA Kazuto
Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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SHINOHARA HIROYUKI
Department of Oral Surgery, Asahi University, School of Dentistry
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MEENAGHAN MICHAEL
Department of Oral Pathology, State University of New York at Buffalo
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Tanaka Toshikazu
Department Of Anatomy Faculty Of Medicine Kyoto University
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Tanaka Takaaki
Department Of Oral Surgery Asahi University School Of Dentistry
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Shinohara Hiroyuki
Department Of Oral Surgery Asahi University School Of Dentistry
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Tanaka T
Department Of Oral Anatomy And Cell Biology Graduate School Of Dental Sciences Kyushu University
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Shinohara Haruo
Department Of Oral Surgery Asahi University School Of Dentistry
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Tanaka Tomoo
Division Of Basic Medical Sciences Tokai University School Of Medicine
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Yamada Kazuto
Department Of Inherited Metabolic Disease National Institute Of Neuroscience National Center Of Neur
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Muto Masahiro
Department Of Oral Pathology Osaka Dental University
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Tanaka Takaaki
Department Of Geoscience Joetsu University Of Education
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Takai Yoshiaki
Depertment Of Oral Surgery Gifu College Of Dentistry
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Mori Masahiko
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Tanaka Takaaki
Department Of Biotechnology Faculty Of Engineering Okayama University
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Mori Masahiko
Department Of Applied Chemistry Faculy Of Engineering And High Technology Research Center Kansai Uni
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Shinohara Hiroyuki
Department Of Applied Chemistry Graduate School Of Engineering Osaka Prefecture University
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Meenaghan Michael
Department Of Oral Pathology State University Of New York At Buffalo
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Tanaka Takaaki
Department Of Bioscience & Biotechnology Faculty Of Engineering Okayama University
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Takai Yoshiaki
Department of Electrical Engineering and Computer Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
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