Comparative Expression of E-cadherin, α and β Catenin in Salivary Gland Tumors
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概要
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To study the expression and role of adhesion molecules in normal salivary glands and their tumors, we have studied simultaneously the expression of E-cadherin. and associated cytoplasmic proteins, α-catenin and β-catenin. Paraffin sections were evaluated using the streptavidin biotin peroxidase complex (SBPC) method for E-cadherin. and the SBPC method with tyramide signal amplification (TCA) for α- and β-catenin. Normal submandibular (n=10), parotid (n=4) and oral minor glands (n=4) showed cell membrane staining for E-cadherin and a positive reaction in intercalated and striated ducts for α- and β-catenin. Pleomorphic adenoma (n=17) showed cell membrane staining for E-cadherin and α-catenin in luminal and non-luminal cells. but were negative for β-catenin. E-cadherin was also focally or irregularly positive in modified myoepithelial cells. Warthin's tumors (n=4) expressed E-cadherin only and were negative for α- and β-catenins. Papillary adenocarcinoma (n=4) showed predominant staining for E-cadherin, with no expression in the other tumor cells. Adenoid cystic carcinoma (n=4) showed only cell membrane positivity for E-cadherin, with an absence of α- and β-catenins in the luminal cells. Non-luminal tumor cells of adenoid cystic carcinoma were negative for E-cadherin and positive for α- and β-catenins. The results were concluded as follows. 1) there was uniform cell membrane staining for E-cadherin in normal and benign tumor epithelium. but α- and β-catenins showed different expression and heterogeneous localization. 2) loss of E-cadherin reactivity was seen in malignant lesions, 3) there was no correlation between the distribution of E-cadherin. α-catenin and β-catenin in benign or malignant tumors of salivary gland origins. The results show variability and heterogeneous expression for E-cadherin, α- and β-catenins in salivary gland tumors.
- 日本組織細胞化学会の論文
著者
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TAKAI Yoshiaki
Department of Electronics Engineering, Nagoya University
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MORI Masahiko
Department of Oral Pathology, Osaka Dental University
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Mori M
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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Yamada K
Department Of Anatomy School Of Health Sciences Fujita Health University
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Yamada Keiki
Dept. Anat. Sch. Hygiene Fujita-gakuen Univ.
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Yamada K
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry:department Of Oral
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Takai Y
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry
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Takai Yoshiaki
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Mori M
Department Of Oral And Maxillofacial Surgery School Of Dentistry Asahi University
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Mori M
Department Of Oral Surgery Asahi University School Of Dentistry
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Mori M
Department Of Oral Surgery Gifu College Of Dentistry
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TSUKITANI KOUJI
Department of Dentistry, Kyoto Prefectural University of Medicine
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YAMADA Kazuto
Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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NAMBA Miyako
Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry
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Kudeken Wataru
Department of Oral and Maxiillofacial Surgery, Asahi University School of Dentistry
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Yang Lian
Department of Oral Pathology, The 4th Military Medical University, Xian, China
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Speight Paul
Department of Oral Pathology, Eastman Dental Institute, University of London
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Mori Masahiko
Takasago Research & Development Center Mitsubishi Heavy Industries Ltd.
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Mori Masahiko
Radiation Hazards Research Group National Institute Of Radiological Sciences
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Yang Lian
Department Of Oral Pathology The 4th Military Medical University Xian China
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Speight Paul
Department Of Oral Pathology Eastman Dental Institute University Of London
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Namba Miyako
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Yamada Kazuto
Department Of Inherited Metabolic Disease National Institute Of Neuroscience National Center Of Neur
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Kudeken Wataru
Department Of Oral And Maxiillofacial Surgery Asahi University School Of Dentistry
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Muto Masahiro
Department Of Oral Pathology Osaka Dental University
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Takai Yoshiaki
Depertment Of Oral Surgery Gifu College Of Dentistry
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Mori Masahiko
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Tsukitani Kouji
Department Of Oral & Maxillofacial Surgery Kyoto Prefectural University Of Medicine
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Mori Masahiko
Department Of Applied Chemistry Faculy Of Engineering And High Technology Research Center Kansai Uni
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Takai Yoshiaki
Department of Electrical Engineering and Computer Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
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