Aberrant Expression Patterns of Histone H3 mRNA, p53, Cyclin D1, and Cyclin B1 in Oral Neoplastic Epithelial Lesions
スポンサーリンク
概要
- 論文の詳細を見る
In this paper, tumor growth was studied using oncogenic and kinetic analysis. In verrucous carcinoma (VC, n=22), squamous papilloma (SP, n=18), and hyperkeratotic lesion (HK, n=12), cellular proliferative potentials were evaluated and compared. Co-expression of histone H3 mRNA and p53 protein was not found in HK. In 6 cases (33.3%) of SP, co-expression was detected within the basal and parabasal layers. However, in 17 cases (77.2%) of VC, co-expression of histone H3 mRNA and p53 protein was found extensively from basal to spinous layers. Cyclin D1 was detected in 5 cases (41.7%) of HK and in 14 cases (77.8%) of SP at parabasal layer. While in 20 cases (90.9%) of VC, cyclin D1 was detected from basal to spinous layers, and positive (2+ and 3+) cases (45.4%) increased. Cyclin B1 was detected in 9 cases (75.0%) of HK and in 16 cases (88.9%) of SP at basal or parabasal layer, and in all 22 cases of VC from basal to spinous layers, and positive (2+ and 3+) cases (68.1%) increased. In the intra-cellular distribution of cyclin B1, there were many cases of cytoplasmic types (66.7%) in HK, of cytoplasmic dominant types (50.0%) in SP, and of cytoplasmic dominant types (72.7%) in VC. There were also some cases of nuclear dominant types (27.3%) in VC. The present study suggests that increase of p53 protein, increase of cell proliferation, wide epithelial distribution of cyclins D1 and B1, and increase of positive cells in the nucleus with cyclin B1 were indicators of malignant potential.
- 日本組織細胞化学会の論文
著者
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Wato Masahiro
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department Of Oral Pathology Osaka Dental University
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Wato Masahiro
大阪歯科大学 口腔病理学
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Wato Masahiro
Department Of Oral Pathology Osaka Dental University
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Arika Takumi
Department Of Oral And Maxillofacial Surgery National Hospital Organization Osaka National Hospital
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Arika Takumi
大阪歯科大学 第二口腔外科学
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Arika Takumi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Nishikawa Tetsunari
Department of Oral Pathology, Osaka Dental University
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Nishikawa Tetsunari
Department Of Oral Pathology Osaka Dental University
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Nishikawa Tetsunari
大阪歯科大学 口腔病理学
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MASUNO Kazuya
Department of Oral Pathology, Osaka Dental University
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TOMINAGA Kazuya
Department of Oral Pathology, Osaka Dental University
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WATANABE Yuya
Department of Oral Pathology, Osaka Dental University
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MORI Masahiko
Department of Oral Pathology, Osaka Dental University
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Watanabe Yuya
Osaka Dental Univ. Osaka Jpn
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Watanabe Yuya
Department Of Oral Pathology Osaka Dental University
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Tominaga Kazuya
Department Of Oral Pathology Osaka Dental University
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Mori M
Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio
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Mori Masahiko
Department Of Oral Pathology Osaka Dental University
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Tominaga Kazuya
Osaka Dental Univ. Osaka Jpn
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Tanaka Akio
Osaka Dental Univ. Osaka Jpn
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Wato Masahiro
Osaka Dental Univ. Osaka Jpn
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ITO YUICHI
Department of Urology, Chubu Rosai Hospital
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Mori M
Department Of Oral And Maxillofacial Surgery School Of Dentistry Asahi University
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Mori M
Department Of Oral Surgery Asahi University School Of Dentistry
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Mori M
Department Of Oral Surgery Gifu College Of Dentistry
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伊藤 雄一
大阪歯科大学大学院歯学研究科病理学専攻
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Hara Ryohko
Department of Oral Pathology, Osaka Dental University
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Mori Masahiko
Takasago Research & Development Center Mitsubishi Heavy Industries Ltd.
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Mori Masahiko
Radiation Hazards Research Group National Institute Of Radiological Sciences
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Tanaka A
Department Of Oral Pathology Osaka Dental University
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Tanaka Akio
大阪歯科大学 口腔病理学
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Ito Yuichi
Department Of Oral Pathology Osaka Dental University
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Hara Ryohko
Department Of Oral Pathology Osaka Dental University
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Masuno Kazuya
Department Of Oral Pathology Osaka Dental University
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Muto Masahiro
Department Of Oral Pathology Osaka Dental University
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Mori Masahiko
Department Of Oral And Maxillofacial Surgery Asahi University School Of Dentistry
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Mori Masahiko
Department Of Applied Chemistry Faculy Of Engineering And High Technology Research Center Kansai Uni
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Tanaka Akio
Department Of Electrical Engineering Nagaoka University Of Technology
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Ito Yuichi
Department of Cardiology Isesaki-Sawa Medical Association Hospital
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