Immunohistochemical study of the periodontal tissues of model rats with type 2 diabetes mellitus
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概要
- 論文の詳細を見る
We investigated the relation between periodontal tissue and type 2 diabetes mellitus and attempted to clarify the distribution of osteoclasts, macrophages, collagens and blood capillaries in periodontal tissue with the diabetes. We immunohistochemically examined CD68-positive cells, type 3 and type 4 collagens, and enzyme histochemically examined TRAP-positive cells in the periodontal tissues of the Goto-Kakizaki (GK) rat, which is a type 2 diabetes model rat. Wistar rats were used as controls. There were many macrophages and osteoclasts in the periodontal tissue of the diabetes mellitus rats at 2 months of age (DM-2M), whereas localization of type 3 collagen was the same as in the controls. There was an increased tendency for localization of type 4 collagen in the experimental animals compared DM-2M with the controls (NDM-2M). These results suggest that diabetes plays an important role as a risk factor for periodontitis.
- 大阪歯科学会の論文
著者
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Tanaka Akio
Department Of Oral Pathology Osaka Dental University
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Ueda Masatoshi
Department Of Periodontology Osaka Dental University
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Ueda Mika
Graduate School of Dentistry (Periodontology), Osaka Dental University
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Ueda Mika
Graduate School Of Dentistry (periodontology) Osaka Dental University
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Tanaka Akio
Department Of Electrical Engineering Nagaoka University Of Technology
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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