Influence of a neuropeptide on cytokine network : Influence of substance P on proinflammatory cytokine mRNA expression in recombinant human tumor necrosis factor-α-stimulated human dental pulp-derived cells
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概要
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Substance P (SP) enhances TNF-α mRNA expression in lipopolysaccharide (LPS)-stimulated dental pulp-derived cells. We investigated the influence of SP on proinflammatory cytokine mRNA expression in TNF-α-stimulated dental pulp-derived cells. We used human dental pulp-derived cells (HDPC) collected from a first premolar extracted for orthodontic treatment. SP enhanced mRNA expression of only TNF-α among the proinflammatory cytokines expressed in response to LPS stimulation, whereas it enhanced IL-1β, TNF-α, IL-8 and IL-6 mRNA expressions (all measured cytokine mRNAs) among the proinflammatory cytokines expressed in response to TNF-α stimulation. This tendency was strong when cells were stimulated with TNF-α at a low level. The results suggest that SP contributes to the expansion of inflammation by enhancing the cytokine network.
- 2013-04-00
著者
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Shida Muneyasu
Department of Endodontics, Osaka Dental University
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Shida Muneyasu
Department Of Endodontics Osaka Dental University
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Taguchi Yoichiro
Department Of Periodontology Osaka Dental University
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Hayashi Hiroyuki
Department Of Applied Chemistry Faculty Of Engineering Osaka Institute Of Technology
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Umeda Makoto
Department Of Advanced Regulatory Vascular Surgery Tokyo Medical And Dental University
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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HAYASHI Hiroyuki
Department of Advanced Energy, University of Tokyo, Kashiwa, Chiba 277-8561, Japan
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