Establishment and Characterization of a Human Tongue Cancer Xenograft Line in Nude Mice
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概要
- 論文の詳細を見る
We established a human tongue cancer (well-differentiated squamous cell carcinoma) xenograft line, LK-1, in nude mice. LK-1 showed logarithmic growth from 5 to 7 weeks after transplantation, and the take rate for 25 generations was 95.0%. We confirmed the expression of cytokeratins 1, 5, 7, 10, 14, 16, 17, 18 and 19, and type I, III, IV and V collagens by electrophoretical and immunohistochemical analyses. Although the amount of type I, IV and V collagens increased gradually from 5 weeks after transplantation, the distribution of type IV collagen was often discontinuous in the cancer basement membrane. From these data we concluded that LK-1 is an excellent model for the investigation of the cell biology of well-differentiated oral squamous cell carcinoma, and for examining the effects of clinical therapies for this disease.
- 大阪歯科学会の論文
著者
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Tamura Isao
Department of Biochemistry Osaka Dental University
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Wato Masahiro
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department Of Oral Pathology Osaka Dental University
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Wato Masahiro
大阪歯科大学 口腔病理学
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Wato Masahiro
Department Of Oral Pathology Osaka Dental University
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SAKAKI Tetsuya
Department of Biochemistry, Osaka Dental University
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Arika Takumi
大阪歯科大学 第二口腔外科学
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Arika Takumi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Sakaki Toshio
Second Department of Oral and Maxillofacial Surgery, Osaka Dental Universty
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Shirasu Rikiya
First Department of Oral and Maxillofacial Surgery, Osaka Dental University
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Sakaki Tetsuya
Department Of Biochemistry Osaka Dental University
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Sakaki Tetsuya
大阪歯科大学 第2口腔外科
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Shirasu R
Osaka Dental Univ. Osaka Jpn
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Shirasu Rikiya
大阪歯科大学 歯研究 細菌
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Shirasu Rikiya
First Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Sakaki T
Second Department Of Oral And Maxillofacial Surgery Osaka Dental Universty
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Tanaka Akio
Osaka Dental Univ. Osaka Jpn
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Wato Masahiro
Osaka Dental Univ. Osaka Jpn
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Sakaki Toshio
Department Of Biochemistry Osaka Dental University
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SAKAKI Toshio
First Department of Oral and Maxillofacial Surgery, Osaka Dental University
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AOKI Sachiko
Department of Biochemistry, Osaka Dental University
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Aoki Sachiko
Department Of Biochemistry Osaka Dental University
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Tanaka Akio
Department Of Electrical Engineering Nagaoka University Of Technology
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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