Basic fibroblast growth factor induces the expression of early growth response-1 in human periodontal ligament fibroblasts
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概要
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We investigated the effect of basic fibroblast growth factor (bFGF) on the expression of early growth response (EGR)-1 in human periodontal ligament fibroblasts (PDLFs). When expressions of EGR-1 mRNA and protein were monitored as a function of increased doses of bFGF, they were found to gradually increased over time. Immunocytochemically, reaction to the anti-EGR-1 antibody was strong in the intercellular region. EGR-1 expression was particularly strong in the nuclear region after 60 min. These results demonstrate that bFGF induced the expression of EGR-1 at low concentrations, and that EGR-1 potentially plays an important role in PDLF growth.
- 大阪歯科学会の論文
著者
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Tamura Isao
Department of Biochemistry Osaka Dental University
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Ikeo Takashi
Department of Biochemistry Osaka Dental University
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Tamura Isao
大阪歯科大学 生化学
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Ikeo Takashi
大阪歯科大学 生化学
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