Alteration of Decorin Synthesis in Gingival Fibroblasts Induced by Interleukin-1β

概要

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Decorin, a small dermatan sulfate proteoglycan, binds to collagen, and is known to related to fibrillogenesis. To elucidate the fluctuation of decorin mRNA during the process of inflammation, we examined its expression in cultured human gingival fibroblasts stimulated by interluekin (IL)-1β. Matrix metalloproteinases (MMP)-3, type I collagen and IL-6 mRNA expression were also determined. The effects of IL-1β on the expression of decorin and type I collagen mRNA were similar to each other. Their mRNA expression levels compared with controls were increased with culture time up to 24h, followed by a decrease to 48h. Although the mRNA levels of MMP-3 and IL-6 were trace in controls, they increased markedly by stimulation of IL-1β. These results indicate that gingival fibroblasts stimulated by IL-1β actively express IL-6 mRNA as an early event of inflammation, followed by decorin, type I collagen and MMP-3, which are associated with collagen fibrils, in events coexisting with destruction and repair.
日本再生歯科医学会の論文
2004-03-30