Inhibitory effects of four Chinese herbal medicines on oral squamous cancer cell lines

概要

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We examined the inhibitory effect of Gypenoside (GP), Baicalia (BC), Salvia miltiorrhiza (SM), and Erigeron breviscapus (EB) to determine whether Chinese herbal medicines are effective against oral cancer. Phenazine methosulfate-methyl thiazoly tetrazolium (PMSMTT) assay was performed on the oral squamous cancer cell lines Tca-8113 and CAL-27. The ID 50 of the four Chinese herbal medicines was calculated. We found that BC and EB were the most effective. The ID 50 values for Tca-8113 and CAL-27 of BC were 128.63μmol/L and 117.79μmol/L, respectively. They were 223.18μmol/L and 1010.98μmol/L, respectively for EB. The ID 50 for the combined effect of BC and EB, was 27.131μmol/L for Tca-8113 and 20.674μmol/L for CAL-27. Thus BC and EB had a synergistic effect in inhibiting Tca-8113 and CAL-27 (CI<1).