In vivo behavior of surface-modified titanium implants after chemical processing at room temperature

概要

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We evaluated new bone formation on the nano-modified surfaces of titanium plates implanted in the rat femur by comparing the ratio of bone-to-implant contact (%BIC). To create the nanostructure, titanium discs were incubated in a 10 M NaOH solution at 30℃ for 24 h, and then washed and dried. Plates of titanium with nanostructures (the experimental group) and unprocessed titanium 1 mm thick and 4 mm in diameter (control group) were implanted into the femurs of the rats. After 14, 21 and 28 weeks, the %BIC for the control and experimental groups was 0.2% and 3.6% at 2 weeks, 18.2% and 24.7% at 3 weeks, 37.5% and 53.0% at 4 weeks respectively. These data suggest that modifying the nanostructure of the titanium surface, which is one of the main materials used in implants, allows induction of bone formation.
大阪歯科学会の論文