Polyethylene Glycol Interferon α-2b-induced Immune-mediated Polyradiculoneuropathy
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概要
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Polyethylene glycol-interferon ﾎｱ (PEG-IFNﾎｱ) has been used as the standard treatment for hepatitis C virus (HCV) infection. There have been no previous reports of polyradiculoneuropathy with anti-ganglioside antibodies induced by PEG-IFNﾎｱ-2b. We report a 59-year-old man who developed polyradiculoneuropathy during treatment with PEG-IFN ﾎｱ-2b for chronic HCV infection. Serum levels of anti-asialo-GM1 (GA1) and anti-GM1 antibodies were elevated. Cessation of therapy with double filtration plasmapheresis resulted in marked improvement in his symptoms accompanied by a reduction in the antibody level. PEG-IFN ﾎｱ-2b may induce peripheral neuropathy mediated by anti-GA1 and anti-GM1 antibodies. © 2009 The Japanese Society of Internal Medicine.
著者
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Kusunoki Susumu
Department Of Neurology Graduate School Of Medicine University Of Tokyo
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Takahashi Kazuya
Department Of Chemistry The University Of Tokyo
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Yamada Masahito
Department Of Neurology & Neurobiology Of Aging Kanazawa University Graduate School Of Medical S
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Ishida Chiho
Department of Neurology and Center for Neuroscience, University of California at Davis
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Kato-Motozaki Yuko
Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science
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Koma Kiyonobu
Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science
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Ueda Masami
Department of Neurology, Kinki University School of Medicine
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Komai Kiyonobu
Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science
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