The Inductive Effect of Bone Morphogenetic Protein (BMP) on Human Periodontal Fibroblast-like Cells In Vitro
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概要
- 論文の詳細を見る
Bone morphogenetic protein (BMP) has the capability of 1) inducing bone formation in non-bone tissue such as muscle, 2) promoting proliferation and differentiation of human dental pulpal cells, and 3) inducing early formation of both osteodentin and regular tubular dentin. In addition, when BMP is implanted in periodontal defects, it stimulates regeneration of periodontal tissues. In the present study, we sought to explore the mechanisms by which BMP induces these effects, using immunohistochemical methods to investigate periodontal fibroblast-like cells in vitro. Cellular production of fibronectin, endogenous BMP and alkaline phosphatase were measured using image analysis of immunohistochemical reactivity. Periodontal fibroblast-like cells incubated with exogenous BMP showed decreased alkaline phosphatase activity, unchanged fibronectin production, but increased expression of endogenous BMP compared with control specimens incubated without BMP. These data suggest that regenerative as well as inductive effects of BMP on undifferentiated periodontal mesenchymal cells may be mediated through its ability to modulate cellular expression of these substances.
- 大阪歯科学会の論文
著者
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Fang Yi-ru
Department of Dental Oriental Medicine, Osaka Dental University
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Tanaka Akio
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department Of Oral Pathology Osaka Dental University
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Arika Takumi
大阪歯科大学 第二口腔外科学
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Arika Takumi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Fang Yi-ru
中華人民共和国
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Fang Y‐r
Department Of Anesthesiology Osaka Dental University
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Fang Yi-ru
Department Of Oral Pathology Osaka Dental University
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Tanaka Akio
Osaka Dental Univ. Osaka Jpn
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GAO Yuhao
Department of Oral Pathology Qindu Stomatological College, Fourth Military Medical University
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YANG Lianjia
Department of Oral Pathology Qindu Stomatological College, Fourth Military Medical University
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MORI Masakazu
Department of Oral Pathology, Osaka Dental University
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KAWAHARA Koji
Department of Oral Pathology, Osaka Dental University
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Fang Yi-ru
Department Of Anesthesiology Osaka Dental University
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Gao Yuhao
Department Of Oral Pathology Qindu Stomatological College Fourth Military Medical University
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Yang Lianjia
Department Of Oral Pathology Qindu Stomatological College Fourth Military Medical University
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Mori M
Department Of Information Network Engineering Aichi Institute Of Technology
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Mori Masakazu
Department Of Anesthesiology Faculty Of Medicine Oita University
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Kawahara Koji
Department Of Oral Pathology Osaka Dental University
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Tanaka Akio
Department Of Electrical Engineering Nagaoka University Of Technology
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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