Expression of p21, p27, p53, cyclin D 1 and thymidylate synthase in squamous cell and mucoepidermoid carcinomas
スポンサーリンク
概要
- 論文の詳細を見る
In order to understand the differences in cell-cycle progression between well differenciated squamous cell carcinomas (SCC) and mucoepidermoid carcinomas (MEC) we examined formalin-fixed, paraffin-embedded sections of 27 SCCs and 22 MECs immunohistochemically with anti-human p53, p21, p27, cyclin D 1 and thymidylate synthase (TS) antibodies. The sections were stained with DAB and hematolyin. Positivities of p53, p21 cyclin D 1, and TS in SCC were greater than in MEC. On the other hand, p27 positivity was greater in MEC. These results indicate that MEC has fewer p53 mutations or damaged DNA, many cells in MEC are arrested in the G_0 phase by p27 and rarely progress to the S phase in comparison with SCC.
- 大阪歯科学会の論文
著者
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Tanaka Akio
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department Of Oral Pathology Osaka Dental University
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Arika Takumi
Department Of Oral And Maxillofacial Surgery National Hospital Organization Osaka National Hospital
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Arika Takumi
大阪歯科大学 第二口腔外科学
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Arika Takumi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Nishikawa Tetsunari
Department of Oral Pathology, Osaka Dental University
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Nishikawa Tetsunari
Department Of Oral Pathology Osaka Dental University
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Nishikawa Tetsunari
大阪歯科大学 口腔病理学
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MASUNO Kazuya
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Osaka Dental Univ. Osaka Jpn
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Tanaka A
Department Of Oral Pathology Osaka Dental University
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Tanaka Akio
大阪歯科大学 口腔病理学
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Masuno Kazuya
Department Of Oral Pathology Osaka Dental University
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Tanaka Akio
Department Of Electrical Engineering Nagaoka University Of Technology
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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