Immunohistochemical expression of P-cadherin and cyclin D1 in oral epithelial dysplasia
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概要
- 論文の詳細を見る
We investigated how oral epithelial dysplasia (OED) relates to the expressions of Pcadherin and cyclin D1 using biopsy specimens of 32 cases of OED, with 20 cases of oral squamous cell carcinoma (OSCC) as controls. In normal oral epithelium and mild OED, the expression of P-cadherin is observed in the cell membrane of the basal cell layer, except on the basement membrane side, and the expression of cyclin D1 is observed in the nuclei of a few basal cells. We observed strong expression of P-cadherin in the cell membrane and cytoplasm of most cells with severe OED and in cancer cells with OSCC. There was a significant correlation between the expression of P-cadherin and the severity of OED (p<0.05). Although the expression of cyclin D1 was observed in nuclei of OED cells and OSCC cells, there was no correlation between the expression of cyclin D1 and the severity of OED (p=0.55). These results suggest that P-cadherin is involved in cell proliferation.
- 大阪歯科学会の論文
著者
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Tanaka Makoto
Department of Intensive Care, Anesthesiology, Surgery and Internal Medicine, Univ. of Tsukuba
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Wato Masahiro
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department of Oral Pathology, Osaka Dental University
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Tanaka Akio
Department Of Oral Pathology Osaka Dental University
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Wato Masahiro
大阪歯科大学 口腔病理学
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Wato Masahiro
Department Of Oral Pathology Osaka Dental University
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Arika Takumi
Department Of Oral And Maxillofacial Surgery National Hospital Organization Osaka National Hospital
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Arika Takumi
大阪歯科大学 第二口腔外科学
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Arika Takumi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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HIDA Tomoaki
Department of Oral Pathology, Osaka Dental University
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WATANABE Yuya
Department of Oral Pathology, Osaka Dental University
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Tsunokuma Masayuki
大阪歯科大学 口腔病理学
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Watanabe Yuya
Osaka Dental Univ. Osaka Jpn
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Watanabe Yuya
Department Of Oral Pathology Osaka Dental University
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Hida Tomoaki
Osaka Dental Univ. Osaka Jpn
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Hida Tomoaki
Department Of Oral Pathology Osaka Dental University
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Tanaka Akio
Osaka Dental Univ. Osaka Jpn
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Wato Masahiro
Osaka Dental Univ. Osaka Jpn
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Tanaka M
Department Of Oral Pathology Osaka Dental University
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Tanaka A
Department Of Oral Pathology Osaka Dental University
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Tanaka Akio
大阪歯科大学 口腔病理学
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Tanaka Makoto
Department Of Cardiovascular Medicine University Of Tokyo
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Tanaka Makoto
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Tanaka Makoto
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Tanaka Makoto
Department Of Cardiology Cardiovascular Center Osaka Red Cross Hospital
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Tanaka Makoto
Department Of Adult Nursing/palliative Care Nursing Graduate School Of Medicine The University Of To
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Tanaka Akio
Department Of Electrical Engineering Nagaoka University Of Technology
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Tanaka Akio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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