Prostaglandin D2 Inhibits IgE-Mediated Scratching by Suppressing Histamine Release From Mast Cells
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概要
- 論文の詳細を見る
Effects of prostaglandin (PG) D2, PGE2, and PGI2 on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined. PGD2 and ketotifen but not PGE2 and PGI2 suppressed the scratching caused by ovalbumin injected into ovalbumin-sensitized mice. Ketotifen also suppressed compound 48/80-induced scratching but not PGD2, PGE2, and PGI2. In vitro, PGD2 suppressed the antigen-induced histamine release from RBL-2H3 cells, but PGE2 and PGI2 did not. These findings suggest that PGD2 specificically suppressed IgE-mediated scratching by inhibiting IgE-mediated histamine release from mast cells.
- 社団法人 日本薬理学会の論文
著者
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Tanaka Makoto
Department of Intensive Care, Anesthesiology, Surgery and Internal Medicine, Univ. of Tsukuba
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HASHIMOTO Yuki
Department of Human and Information Science, Tokai University
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Nakaike Shiro
Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.
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Hashimoto Yuki
Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.
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Arai Iwao
Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.
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Arai Iwao
Department Of Pharmacological Evaluation Laboratory Self Medication Laboratory Taisho Pharmaceutical
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Tanaka Makoto
Department Of Cardiovascular Medicine University Of Tokyo
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Tanaka Makoto
Department Of Cardiology Cardiovascular Center Osaka Red Cross Hospital
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Tanaka Makoto
Department Of Anesthesiology And Critical Care Medicine Institute Of Clinical Medicine Graduate Scho
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Tanaka Makoto
Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.
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Tanaka Makoto
Department Of Adult Nursing/palliative Care Nursing Graduate School Of Medicine The University Of To
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Hashimoto Yuki
Department Of Astronomy Kyoto University
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HASHIMOTO Yuki
Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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Tanaka Makoto
Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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NAKAIKE Shiro
Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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ARAI Iwao
Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.
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