Prostaglandin D2 Inhibits IgE-Mediated Scratching by Suppressing Histamine Release From Mast Cells

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概要

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• Effects of prostaglandin (PG) D2, PGE2, and PGI2 on itch-associated scratching responses of mice and histamine release from the rat basophilic leukemia cell line RBL-2H3 were examined. PGD2 and ketotifen but not PGE2 and PGI2 suppressed the scratching caused by ovalbumin injected into ovalbumin-sensitized mice. Ketotifen also suppressed compound 48/80-induced scratching but not PGD2, PGE2, and PGI2. In vitro, PGD2 suppressed the antigen-induced histamine release from RBL-2H3 cells, but PGE2 and PGI2 did not. These findings suggest that PGD2 specificically suppressed IgE-mediated scratching by inhibiting IgE-mediated histamine release from mast cells.

• 社団法人 日本薬理学会の論文

著者

• Tanaka Makoto

  Department of Intensive Care, Anesthesiology, Surgery and Internal Medicine, Univ. of Tsukuba

• HASHIMOTO Yuki

  Department of Human and Information Science, Tokai University

• Nakaike Shiro

  Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.

• Hashimoto Yuki

  Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.

• Arai Iwao

  Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.

• Arai Iwao

  Department Of Pharmacological Evaluation Laboratory Self Medication Laboratory Taisho Pharmaceutical

• Tanaka Makoto

  Department Of Cardiovascular Medicine University Of Tokyo

• Tanaka Makoto

  Department Of Cardiology Cardiovascular Center Osaka Red Cross Hospital

• Tanaka Makoto

  Department Of Anesthesiology And Critical Care Medicine Institute Of Clinical Medicine Graduate Scho

• Tanaka Makoto

  Department Of Pharmacology Laboratory Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.

• Tanaka Makoto

  Department Of Adult Nursing/palliative Care Nursing Graduate School Of Medicine The University Of To

• Hashimoto Yuki

  Department Of Astronomy Kyoto University

• HASHIMOTO Yuki

  Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.

• Tanaka Makoto

  Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.

• NAKAIKE Shiro

  Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.

• ARAI Iwao

  Department of Pharmacology Laboratory, Medicinal Research Laboratory, Taisho Pharmaceutical Co., Ltd.

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