Apoptotic cells in pleomorphic adenomas

概要

論文の詳細を見る
Although apoptosis is generally thought to be inhibited in malignant tumors,the phenomenon is not well understood in benign tumors. We used the terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) method to study apoptosis in pleomorphic adenoma. We found an apoptosis-positive reaction in the nuclei of a few tumor cells that had tubuloductal structures, neoplastic cells in sheets, and myoepithelial cells made up of myxoid structures. More apoptosis-positive cells were found in luminal tumor cells of tubular and duct-like structures. In oral papillomas, some epithelial cells showed apoptosis-positive reactions in the nucleus, although very few positive cells were seen in the five cases of oral squamous cell carcinomas we examined. We concluded that apoptosis tends to occur in ductal epithelial cells in pleomorphic adenoma and that expression of apoptosis in the cells of benign tumors is different from that in malignant tumors such as cancer.
大阪歯科学会の論文