Detection of human papillomavirus and abnormal expression of tumor suppressor genes in epithelial dysplasias and squamous cell carcinomas of the oral mucosa
スポンサーリンク
概要
- 論文の詳細を見る
We examined the expression of the human papillomaviruses (HPV), p53, mutant type p53, Rb and p16 in oral dysplasia and oral squamous cell carcinoma (SCC). We used 10 samples each of irritation fibroma (IF), low grade dysplasia (LGD), high grade dysplasia (HGD) and SCC obtained from Osaka Dental University Hospital. We detected the DNA of HPV-16 and -18 by polymerase chain reaction (PCR) and the mRNA of HPV by in situ hybridization (ISH). We also studied the immunohistochemical expression of p53, mutant type p53, Rb and p16. HPV-16 was detected in almost all cases of LGD and SCC, but in no cases of ISH. Marked expression of mutant type p53 and Rb was seen in HPV-16 positive LGD and SCC. HPV infections were detected by PCR in almost all cases of HGD and SCC. Specimens that showed over expression of mutant type p53 and Rb were almost all positive for HPV-16. These results suggest that HPV-16 may play an important role in the transformation of p53 and Rb.
- 大阪歯科学会の論文
著者
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Wato Masahiro
Department of Oral Pathology, Osaka Dental University
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Wato Masahiro
大阪歯科大学 口腔病理学
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Wato Masahiro
Department Of Oral Pathology Osaka Dental University
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Morita Shosuke
First Department of Oral and Maxillofacial Surgery, Osaka Dental University
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Morita Shosuke
First Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Morita Shosuke
大阪歯科大学 大学院歯学研究科口腔外科学
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Morita Shosuke
大阪歯科大学 第二口腔外科学
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Morita Shosuke
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Wato Masahiro
Osaka Dental Univ. Osaka Jpn
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Morita Shosuke
Osaka Dental Univ. Osaka Jpn
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Tsuji Kaname
Graduate School of Dentistry (Oral Maxillofacial Surgery), Osaka Dental University
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Tsuji Kaname
Graduate School Of Dentistry (first Department Of Oral And Maxillofacial Surgery) Osaka Dental Unive
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