Healing process of the maxillary tooth extraction wound in GK rats treated with zoledronate
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概要
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Male Goto-Kakizaki (GK) rats approximately 6 weeks of age were used in this study. The experimental group was injected a total of 4 times with zoledronate (ZOL) intravenously over one week. The maxillary left first molars were extracted from the animals one day after the last ZOL administration. The rats were euthanized 1, 2, 4 and 8 weeks after the extraction. Bone morphometric analysis using hematoxylin and eosin (HE) staining and tartrate-resistant acid phosphatase (TRAP) staining was performed. Although histopathological observation showed that the experimental group had delayed healing of the extraction wound compared with the controls at 1 and 2 weeks after the extraction, sequestration was not observed at 4 and 8 weeks. There were significantly fewer osteoclasts in the base of the extraction wound of the experimental group than in the controls during the experimental period. When ZOL was administered to the GK rats, which are a diabetes rat model, bisphos-phonate-related osteonecrosis of the jaws (BRONJ) was not observed. However, it was suggested that the healing process of the extraction wound was delayed by an osteoclast disorder.
- 2013-04-00
著者
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Morita Shosuke
First Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Iseki Tomio
First Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Watanabe Shinya
Graduate School of Dentistry (First Department of Oral and Maxillofacial Surgery), Osaka Dental University
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