Expression of MMP-2 and HB-EGF in keratocystic odontogenic tumors

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概要

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• Some odontogenic cysts have been found to have special biological features that make them distinct from other lesions. This study was conducted to detect the expression of MMP-2 and HB-EGF in keratocystic odontogenic tumors (KCOTs) and to examine the possible predictive value of these markers. Paraffin-embedded tissue specimens of 11 KCOTs were immunohistochemically examined using antibody against MMP-2. Expression of the EGF family mRNA in KCOT was analyzed by real-time RT-PCR. Fathermore, expression of HB-EGF mRNA and protein were examined in KCOT. Nine of the 11 KCOT cases were immunohistochemically reactivity for MMP-2. The immunopositive reaction to MMP-2 was strongly expressed in the cytoplasm of the prickle cells. The expression levels of HB-EGF were high in KCOT. In addition, although high expression levels were detected for amphiregulin (AREG), epigen (EPGN), epiregulin (EREG) and TGF-α mRNA, betacellulin (BTC) and EGF mRNA were not highly expressed. There was high expression of the amount of HB-EGF protein when compared with the primordial cyst. These findings suggest that the aggressive behavior of KCOTs might be explained by the expression of MMP-2 and HB-EGF, which may be valuable markers for the prediction of the biologic behavior of KCOT.

• 大阪歯科学会の論文

著者

• Horii Katsuko

  Second Department Of Oral And Maxillofacial Surgery Osak Dental University

• Ohnishi Yuichi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Fang Yi-ru

  Department Of Anesthesiology Osaka Dental University

• Kakudo Kenji

  Second Department Of Oral And Maxillofacial Surgery Osak Dental University

• Wu Buling

  Department of Oral and Head and Neck Surgery, School of Stomatology, Nanfang Hospital, Southern Medical University

• Lu Xiaozhi

  Department of Oral and Head and Neck Surgery, School of Stomatology, Nanfang Hospital, Southern Medical University

• Yin Xueming

  Department of Oral and Head and Neck Surgery, School of Stomatology, Nanfang Hospital, Southern Medical University

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