Analysis of cancer testis antigens containing BORIS in oral cancer cell lines
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概要
- 論文の詳細を見る
Cancer testis antigens (CTA) are a group of normal testicular proteins. Although their expression appears in cancer cells, it does not appear in somatic cells with the exception of male germ cells. Consequently CTAs are immunogenic in cancer patients, and considered promising target molecules for cancer vaccines. In CTAs, brother of the regulator of imprinted sites (BORIS), which is also known as CCCTC-binding factor-like (CTCFL), is an epigenetic-acting oncogene that supresses the tumor inhibitor functions of CTCF. For this reason, BORIS is thought to be an ideal molecular target for drugs against various cancers. In order to detect CTAs in oral cancer, we used the methylation pattern to select six genes containing BORIS, ACTL7B, PPP3R2, SYCP1, DAZL, and TAF7L. We then analyzed the expression of these genes in oral squamous cell carcinoma cell lines and various mice organs. Expression of only BORIS in these genes was detectable in SAS, HSC-3 and HSC-4. Boris expression in adult mice was restricted to the testes. These findings imply that BORIS might be the target of immunotherapy for oral cancer.
著者
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Kubo Hirohito
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
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Kakudo Kenji
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
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Ohnishi Yuichi
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
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Nakajima Masahiro
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
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Inoue Hiroshi
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental Uni
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Minamino Yuki
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental Uni
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Ugaki Yoshihide
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental Uni
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Dateoka Suguru
Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental Uni
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Inoue Masahiro
Department of Oral Implantology, Osaka Dental University
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Sugitatsu Mitsuchika
Department of Dentistry and Maxillofacial Surgery, Osaka Rad Cross Hospital
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Sugitatsu Mitsuchika
Department Of Dentistry And Maxillofacial Surgery Osaka Rad Cross Hospital
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Nakajima Masahiro
大阪歯科大学 歯科矯正学講座
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Nakajima Masahiro
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Kakudo Kenji
大阪歯科大学 大学院歯学研究科口腔外科学第二
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Kakudo Kenji
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Minamino Yuki
Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ
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Kubo Hirohito
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Dateoka Suguru
Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ
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Ohnishi Yuichi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Ugaki Yoshihide
Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ
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Kakudo K
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Mori Yui
Graduate School Of Dentistry (oral And Maxillofacial Surgery) Osaka Dental University
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Kakudo Kenji
大阪歯科大学 歯学研究科口腔外科学第2
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Nakajima M
Osaka Dental Univ. Hirakata‐shi Jpn
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Ohnishi Y
Osaka Dental Univ. Hirakata‐shi Jpn
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Ohnishi Yuichi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University Hospital
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Inoue Masahiro
Department Of Biochemistry Osaka Medical Center For Cancer And Cardiovascular Diseases
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Inoue Masahiro
Department Of Applied Physics University Of Tokyo
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Kakudo Kenji
Second Department Of Oral And Maxillofacial Surgery Osak Dental University
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Inoue Hiroshi
Second Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Inoue Masahiro
Department of Applied Molecular Bioscience, Yamaguchi University
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SUGITATSU Mitsuchika
Department of Dentistry and Maxiliofacial Surgery, Osaka Red Cross Hospital
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