Effect of EpCAM localization on proliferation of an oral squamous cell carcinoma cell line

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概要

• 論文の詳細を見る

• EpCAM is a cell surface molecule that is known to be highly expressed in several epithelial carcinomas. We previously reported that a gamma secretase inhibitor decreased the proliferation of oral squamous cell carcinoma (OSCC) cell lines. It was known that substrates of gamma secretase include EpCAM, E-cadherin and Notch. Moreover, it has been noted that gamma secretase induces cleavege of EpCAM in squamous cell carcinoma (SCC) cells, and that the alteration of EpCAM localization is related to cell proliferation. In this study, we confirmed that while EpCAM expression was almost not detectable in the tongue of mice, it was EpCAM expressed in OSCC cell lines. We found that cell proliferation was decreased and the localization of EpCAM was altered by gamma secretase inhibitor in OSCC cell line, indicating that EpCAM expression might be related to carcino-genesis in OSCC. This study suggests that the cleavage of EpCAM is induced by gamma secretase in OSCC cell lines, and that the proliferation of OSCC cells might be affected by changes in EpCAM localization.

• 大阪歯科学会の論文

著者

• Kubo Hirohito

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Ohnishi Yuichi

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Sugitatsu Mitsuchika

  Department Of Dentistry And Maxillofacial Surgery Osaka Rad Cross Hospital

• Nakajima Masahiro

  大阪歯科大学 歯科矯正学講座

• Nakajima Masahiro

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Kakudo Kenji

  大阪歯科大学 大学院歯学研究科口腔外科学第二

• Kakudo Kenji

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Tsunokuma Masayuki

  大阪歯科大学附属病院 第2口腔外科

• Tsunokuma Masayuki

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University Hospital

• Inoue Hiroshi

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Minamino Yuki

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Kubo Hirohito

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Dateoka Suguru

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Ohnishi Yuichi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Ugaki Yoshihide

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Kakudo K

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Mori Yui

  Graduate School Of Dentistry (oral And Maxillofacial Surgery) Osaka Dental University

• Kakudo Kenji

  大阪歯科大学 歯学研究科口腔外科学第2

• Nakajima M

  Osaka Dental Univ. Hirakata‐shi Jpn

• Ohnishi Y

  Osaka Dental Univ. Hirakata‐shi Jpn

• Ohnishi Yuichi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University Hospital

• Watanabe Masahiro

  Graduate School of Pharmaceutical Sciences, Tokyo University of Science

• Fujii Tomoko

  Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental Uni

• Dateoka Suguru

  Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

• Tsunokuma Masayuki

  Department of Oral and Maxillofacial Surgery and Dentistry, Kohka Public Hospital

• Tsunokuma Masayuki

  Department Of Oral And Maxillofacial Surgery And Dentistry Kohka Public Hospital

• Fujii Tomoko

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental Univ

• Kakudo Kenji

  Second Department Of Oral And Maxillofacial Surgery Osak Dental University

• Inoue Hiroshi

  Second Department Of Oral And Maxillofacial Surgery Osaka Dental University

• Watanabe Masahiro

  Graduate School Of Dentistry (second Department Of Oral And Maxillofacial Surgery) Osaka Dental University

• Dateoka Suguru

  Second Department Of Oral And Maxillofacial Surgery Graduate School Of Dentistry Osaka Dental University

• SUGITATSU Mitsuchika

  Department of Dentistry and Maxiliofacial Surgery, Osaka Red Cross Hospital

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