OJ-003 Influences of CYP2D6 Genotype on Plasma Concentrations of Carvedilol : a Comparison with Metoprolol and Bisoprolol(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of

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概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2006-03-01

著者

• MATSUKI Akira

  Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• NOZAWA Takashi

  Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• IGAWA Akihiko

  Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• INOUE Hiroshi

  Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama

• Nozawa Takashi

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Matsuki Akira

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Igawa Akihiko

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Igawa Akihiko

  富山医科薬科大学 第2内科

• Inoue Hiroshi

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• Inoue Hiroki

  Department Of Chemistry Faculty Of Science Kyushu University

• Nakadate Teruo

  Second Department Of Internal Medicine University Of Toyama

• TAGUCHI Masato

  Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• HASHIMOTO Yukiya

  Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Matsuki Akira

  Second Department Of Internal Medicine Toyama University Hospital

• Igawa Akihiko

  The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University

• Igawa Akihiko

  The 2nd Department Of Internal Medicine Toyama Medical And Pharmaceutical University

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Harada Yuichi

  Center For Influenza Virus Research National Institute Of Infectious Diseases

• Taguchi Masato

  Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama

• Hashimoto Yukiya

  Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama

• Hashimoto Y

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

関連論文

• A health-related quality of life questionnaire in symptomatic patients with heart failure : Validity and reliability of a Japanese version of the MRF28
• Fluvastatin Attenuates Diabetes-Induced Cardiac Sympathetic Neuropathy in Association With a Decrease in Oxidative Stress
• PJ-647 Short Term Effect of Adaptive Servo Ventilation on Muscle Sympathetic Nerve Activity in Patients with Chronic Heart Failure(PJ109,Heart Failure (Treatment) 3 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
• PE-446 Prognostic Significance of Non-positional Central Sleep Apnea in Patients with Heart Failure(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
• OE-135 Clinical Significance of Slower Oscillatory Ventilation in Heart Failure Patients with Central Sleep Apnea(OE23,Heart Failure (Pathophysiology) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Accumulation of Risk Factors Increases Risk of Thromboembolic Events in Patients With Nonvalvular Atrial Fibrillation(Clinical Investigation)
• Attitudes of Japanese Cardiologists Toward Anticoagulation for Nonvalvular Atrial Fibrillation and Reasons for Its Underuse
• Effects of Anticoagulation Intensity on Hemostatic Markers in Patients With Non-Valvular Atrial Fibrillation
• Combination with Clinical Risk Factors and Hemostatic Markers Could Better Predict the Risk for Theomboembolism in Patients with Atrial Fibrillation
• Dose-Response Effects of Bepridil in Patients With Persistent Atrial Fibrillation Monitored With Transtelephonic Electrocardiograms : A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (J-BAF Study)
• OJ-078 Impact of Gender Differences in Prevalence of Risk Factors in Patients with Atrial Fibrillation in Japan : Observations from J-TRACE Study(OJ13,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Oral Presentation (Japanese),The 73rd Annual Sci
• PJ-373 Non-invasive Evaluation of Coronary Plaque by 64-Slice Multi-Detector Computed Tomography : Comparison with Intravascular Ultrasound Derived Virtual Histology(CT/DSA-6 (I) PJ63,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meetin
• PJ-037 Effects of a Central Sympathoinhibitory Drug, Guanfacine, on Cardiac Metaiodobenzylguanidine Scintigraphy in Patients with Heart Failure(Nuclear Cardiology 3 (I) : PJ7)(Poster Session (Japanese))
• Supersensitive Response to Isoproterenol in Patients With Marked Global Reduction of Cardiac Metaiodobenzylguanidine Uptake
• Cardiac Sympathetic Nerve Activity Alters Myocardial BMIPP Uptake and Its Clearance
• Sympathetic Neuronal Function Is Coupled with the Downregulation of β-Adrenoceptors in Ischemia-Reperfusion Rat Hearts
• A Brief Episode of Myocardial Ischemia before Acute Myocardial Infarction May Attenuate the Cardiac Sympathetic Nerve Injury
• P578 RESPONSES OF THE LEFT VENTRICLE WITH SYMPATHETIC NEURAL DYSFUNCTION TO ADRENERGIC STIMULATION BY EXERCISE
• P171 SIGNIFICANCE OF TOTAL MIBG DEFECT
• PJ-137 Identification of Low or High Risk for Thromboembolic Events with D-dimer Levels in Patients with Atrial Fibrillation(Thromboembolism/Antithrombotic therapy/Thrombolysis-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• 5 Stratification of NVAF Patients According to Risk Factors for Thromboembolism and Plasma Levels of Hemostatic Markers(Comprehensive Therapeutic Strategy of Atrial Fibrillation, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Thrombogenesis Is Activated in Patients with Nonvalvular Atrial Fibrillation and Risk Factors for Embolism
• Adherence to the Guideline of Prevention of Embolism in Patients with Nonvalvular Atrial Fibrillation
• Novel LAMP-2 Mutation in a Family With Danon Disease Presenting With Hypertrophic Cardiomyopathy
• Relation of Circulating Blood Volume to Left Ventricular Geometry in Essential Hypertension
• Relationship between Electrocardiofraphic Voltage and Geometric Patterns of Left Ventricular Hypertrophy in Patients with Essential Hypertension
• PJ-683 Left Atrial Strain Rate Imaging can be Useful for the Evaluation of Thromboembolic Risk in Patients with Paroxysmal Atrial Fibrillation(PJ115,Thromboembolism/Antithrombotic Therapy/Thrombolysis (IHD),Poster Session (Japanese),The 73rd Annual Scient
• PJ-087 Assessment of Left Atrial Function Using Strain Rate imaging in Patients with Paroxysmal Atrial Fibrillation(Echo/Doppler(12)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-167 Relations Between Serum Levels of Adiponectin and Clinically Determined Thromboembolic Risk in Patients with AF(Thromboembolism / Antithrombotic therapy / Thrombolysis(02)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Ja
• OJ-166 Low Risk Patients Evaluated by ClinicalThromboembolic Risk Schemes Could Have Severe Blood Stasis in Left Atrium in Atrial Fibrillation(Thromboembolism / Antithrombotic therapy / Thrombolysis(02)(H),Oral Presentation (Japanese),The 72nd Annual Scie
• OE-373 Serum Thioredoxin Correlates with Left Atrial Thrombus and Severe Blood Stasis in Left Atrial Appendage in Patients with Atrial Fibrillation(Neurohumoral factors(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese C
• PJ-138 Increased Oxidative Stress with Elevated Serum Thioredoxin Correlates with Blood Stasis in Left Atrial Appendage(Thromboembolism/Antithrombotic therapy/Thrombolysis-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• EFFECT OF EXTRASTIMULATION ON CANINE ECTOPIC ATRIAL AND VENTRICULAR TACHYCARDIA INDUCED BY ACONITINE : Electrophysiology : 46th Annual Scientific Meeting, Japanese Circulation Society
• Morphological changes in capillaries in the ischemic brain in Wistar rats
• Nonlinear Mixed Effects Model Analysis of the Pharmacokinetics of Metoprolol in Routinely Treated Japanese Patients(Biopharmacy)
• 0467 PLASMA SOLUBLE E-SELECTIN, ICAM-1 AND VCAM-1 LEVELS IN SYSTEMIC AND CORONARY CIRCULATION IN PATIENTS WITH VARIANT ANGINA
• P594 INHIBITION OF HUMAN LOW-DENSITY LIPOPROTEIN OXIDATION BY RED WINE AND GRAPE JUICE
• P472 ALTERATIONS OF AUTONOMIC NERVOUS ACTIVITY PRECEDING NOCTURNAL VARIANT ANGINA
• PJ-794 Waon Therapy Improves Exercise Tolerance Primarily through Improvement of Endothelial Function in Patients with Heart Failure(PJ133,Heart Failure (Treatment) 4 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circula
• PJ-110 The Effect of Combined Use of Angiotensin Receptor Blocker with Statin on Coronary Plaque Composition(PJ019,Atherosclerosis (Clinical/Treatment) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
• PJ-450 Impaired Renal Function is Associated with Blunted Heart Rate Recovery Immediately after Exercise(PJ076,Exercise Test/Cardiac Rehabilitation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-543 Focal Myocardial Perfusion Defects Suggest More Advanced Heart Failure in Patients with Dilated Cardiomyopathy(Nuclear cardiology(09)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-014 Fluvastatin Restores Impaired Cardiac Sympathetic Neuronal Function through Reduction in Oxidative Stress in Diabetic Rats(Topics in Nuclear Cardiology(I),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
• PJ-546 Coupling between Vagal Reactivation after Exercise and Cardiac MIBG Findings in Patients with Heart Failure(Nuclear cardiology-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-126 Ischemic Preconditioning-Induced Acceleration of Fatty Acid Oxidation might Result from its Cardioprotective Effect : Influences of Fatty Acid Oxidation Inhibitor(Myocardial ischemia/reperfusion, basic/clinical-3, The 71st Annual Scientific Meeting
• Early Administration of Fluvastatin, but not at the Onset of Ischemia or Reperfusion, Attenuates Myocardial Ischemia-Reperfusion Injury Through the Nitric Oxide Pathway Rather Than Its Antioxidant Property
• Influence of β-Adrenoceptor Blockade on the Myocardial Accumulation of Fatty Acid Tracer and Its Intracellular Metabolism in the Heart After Ischemia-Reperfusion Injury
• Brief Episode of Myocardial Ischemia Before Prolonged Ischemia Attenuates Cardiac Sympathetic Nerve Injury
• PJ-780 Hyperglycemia at Reperfusion Dose Not Exacerbate Myocardial Ischemia-reperfusion Injury(Myocardial ischemia-reperfusion, basic/clinical-6 (IHD) PJ136,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
• PJ-728 A Combined Therapy of AT_1-receptor Antagonist may Enhance the Plaque-stabilizing Effect of Statin(Atherosclerosis, clinical-15 (H) PJ123,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-726 Increase in C-Reactive Protein within Coronary Circulation after Stent Implantation Correlate with Plaque Progression at Non-Culprit Lesion : Effect of Fluvastatin(Atherosclerosis, clinical-15 (H) PJ123,Poster Session (Japanese),The 70th Anniversar
• PE-495 Increase in Necrotic Core Determined by Intravascular Ultrasound Tissue Characterization (Virtual Histology) with the Existence of High-echogenic Material(Intravascular endoscopy/Intravascular ultrasound-3 (I) PE83,Poster Session (English),The 70th
• OJ-003 Influences of CYP2D6 Genotype on Plasma Concentrations of Carvedilol : a Comparison with Metoprolol and Bisoprolol(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of
• FRS-036 Beneficial Effects of Ischemic Preconditioning and Diabetes on Myocardial Fatty Acid Metabolism after Ischemia-reperfusion(Advances in Nuclear Cardiology-2 (I) FRS8,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Ja
• Ischemia-Induced Norepinephrine Release, but not Norepinephrine-Derived Free Radicals, Contributes to Myocardial Ischemia : Reperfusion Injury
• PJ-608 Junctional Rhythm Unassociated with Retrograde Atrial Conduction during Ablation in Atypical Atrioventricular Nodal Reentrant Tachycardia(Arrhythmia, therapy(26)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circula
• Nonlinear Mixed Effects Model Analysis of the Pharmacokinetics of Routinely Administered Bepridil in Japanese Patients with Arrhythmias(Biopharmacy)
• Pharmacokinetic Variability of Routinely Administered Bisoprolol in Middle-Aged and Elderly Japanese Patients(Biopharmacy)
• Reduced Cardiac Norepinephrine Release during Ischemia is not Necessarily Accompanied by Attenuation of Sympathetic Neuronal Dysfunction in the Remote Period (Nuclear Cardiology 11(I), The 69th Annual Scientific Meeting of the Japanese Circulation Society
• The Genotype of CYP2D6 Determines Cardiac Responsiveness to β-adrenergic Stimulation in patients Treated with Metoprolol, but not with Bisoprolol(Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circula
• Improvement of Insulin Signaling Induced by Enalapril Contributes to the Inhibition of Developing Hypertensive Heart Failure of Dahl Rats(Nuclear Cardiology 6 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-550 Early Administration of Fluvastatin, Not at the Onset of Ischemia Or Reperfusion, Reduces Myocardial Infarction Size in Ischemia-Reperfusion Injury(Myocardial Ischemia-Reperfusion, Basic and Clinical 4 (M) : PJ92)(Poster Session (Japanese))
• PJ-098 Nitrates Attenuate Beneficial Effect on Left Ventricular Filling, of Percutaneous Coronary Intervention of Chronic Total Occlusion.(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 4 (IHD) : PJ17)(Poster Session (Japanese))
• PJ-301 Amiodarone Improves the Abnormality of Circadian Variation of Autonomic Function in Rats with Chronic Heart Failure(PJ051,Autonomic Nervous System (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-337 Serial Vascular Remodeling and Regression of Coronary Plaque Components during Statin Treatment(Intravascular endoscopy/Intravascular ultrasound(06)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-329 Exaggerated and sustained adrenergic responses to transient stress in heart and kidney of unanesthetized hypertensive rats(Hypertension, basic(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-072 A combination of assessment of carotid artery plaque with matrix metalloproteinase-9 may predict coronary vulunerable plaque(CT/DSA(07)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• 2 CHADS2 Score is a Useful Scheme for Risk Stratification of Thromboembolism of Japanese Patients with Nonvalvular Atrial Fibrillation(Symposium 6 (SY-06) (A) Recent Strategies for Total Management of Atrial Fibrillation,Special Program,The 72nd Annual Sc
• d,l-Sotalol Reverses Abbreviated Atrial Refractoriness and Prevents Promotion of Atrial Fibrillation in a Canine Model With Left Ventricular Dysfunction Induced by Atrial Tachypacing
• PE-143 Usefulness of Combination Therapy with Bepridil and Amiodarone for Drug-Refractory Atrial Fibrillation in Patients with and without Left Ventricular Dysfunction(Arrhythmia, therapy(07)(A),Poster Session(English),The 72nd Annual Scientific Meeting o
• 1189 UPTAKE AND RELEASE OF ENDOTHELIAL SOLUBLE ADHESION MOLECULES IN CORONARY CIRCULATION IN PATIENTS WITH UNSTABLE ANGINA AND CORONARY SPASM
• OJ-197 Chronic Kidney Disease Enhances Sympathetic Activity in Patients with Heart Failure(Heart failure, clinical(06)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Thoracic Aortic Plaque Enhances Hypercoagulability in Patients With Nonrheumatic Atrial Fibrillation
• OJ-321 Inhibition of Increasing Synaptic Norepinephrine during Ischemia by Valsartan Protects Cardiac Sympathetic Neuronal Function and β-Receptors from Ischemia-Reperfusion Injury(Nuclear Cardiology 7 (I) : OJ38)(Oral Presentation (Japanese))
• OJ-318 Beneficial effects of β-adrenergic blocker in ischemia-reperfusion injury might partially result from the inhibition of non-metabolite accumulation of fatty acid(Nuclear Cardiology 7 (I) : OJ38)(Oral Presentation (Japanese))
• Effects of Valsartan on the Ischemia-Reperfusion Injury of Cardiac Sympathetic Nerve Function and β-Adrenoceptors
• Contributing Factors of Dissociation Between Plasma Norepinephrine Level and Muscle Sympathetic Nerve Activity in Patients with Chronic Heart Failure
• System Identification with Left Ventricular Pressure : Respiratory Flow Relationship for Mechanism of Shallow Respiration in Patients with Heart Failure
• Effect of CYP2D6^*10 on the Pharmacokinetics of R- and S-Carvedilol in Healthy Japanese Volunteers(Biopharmacy)
• Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) : Digest Version
• Multiple Regression Analysis of Pharmacogenetic Variability of Carvedilol Disposition in 54 Healthy Japanese Volunteers(Biopharmacy)
• The Risk Factors for Thromboembolism in Nonvalvular Atrial Fibrillation and CHADS2 Scoring in Japan(Letter to the Editor)
• OJ-326 The Genotype of CYP2D6 Determines the Cardiovascular Responsiveness to Isoproterenol in Patients Treated with Metoprolol(Cardiovascular Pharmacology, Basic/Clinical 2 (H) : OJ39)(Oral Presentation (Japanese))
• OJ-317 Brief Ischemia before Sustained Ischemia Attenuates the Cardiac Sympathetic Nerve Injury via the Reduction of Norepinephrine Release during Ischemia(Nuclear Cardiology 7 (I) : OJ38)(Oral Presentation (Japanese))
• Insulin-Stimulated Glucose Transport and Fatty Acid Oxidation Are Impaired in Hypertrophied Hearts before Heart Failure
• Effect of Carvedilol on Fatty Acid Metabolism in Rat Hearts with Ischemia-Reperfusion Injury
• P303 EFFECTS OF ENARAPRIL ON CARDIAC SYMPATHETIC NEURONAL FUNCTION IN A HYPERTENSIVE HEART FAILURE OF DAHL RATS
• 0772 CHANGES IN CARDIAC SYMPATHETIC NEURONAL FUNCTION AFTER MYOCARDIAL INFARCTION IN RATS
• 0469 THE SIGNIFICANCE OF RENAL MIBG UPTAKE IN RATS : A COMPARISON WITH CARDIAC MIBG UPTAKE
• 0234 AN ASSESSMENT OF CARDIAC ADRENERGIC SIGNAL TRANSDUCTION BY THE DUAL TRACERS IN A HYPERTENSIVE HEART FAILURE OF DAHL RATS
• P135 PROGNOSITIC ASSESSMENT OF OLD MYOCARDIAL INFARCTION
• EVALUATION OF ATRIAL VULNERABILITY WITH WAVE LENGTH AND DISPERSION OF ATRIAL REFRACTORINESS
• Inappropriate Secretion of Antidiuretic Hormone in a Patient with Chronic Inflammatory Demyelinating Polyneuropathy
• Apparent Suppression of Ventricular Parasystole by Cardiac Pacing
• Atorvastatin-Induced Changes in Plasma Coenzyme Q10 and Brain Natriuretic Peptide in Patients With Coronary Artery Disease
• Effects of Acute Changes in Left Ventricular Size on Surface Potential in Man
• "Entrainment" Phenomenon during Reciprocating Tachycardia in the Wolff-Parkinson-White Syndrome
• Pacing Echocardiography : Regional Wall Motion, Left Ventricular Dimension and R Wave Amplitude in Patients with Angina Pectoris
• Impact of myocardial perfusion abnormality on prognosis in patients with non-ischemic dilated cardiomyopathy
• The Risk Factors for Thromboembolism in Nonvalvular Atrial Fibrillation and CHADS2 Scoring in Japan

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